Results 1 to 10 of about 157,329 (161)

Clinical evaluation of synthetic computed tomography methods in adaptive proton therapy of lung cancer patients. [PDF]

Phys Imaging Radiat Oncol, 2023
Background and purpose: Efficient workflows for adaptive proton therapy are of high importance. This study evaluated the possibility to replace repeat-CTs (reCTs) with synthetic CTs (sCTs), created based on cone-beam CTs (CBCTs), for flagging the need of
Taasti VT, Hattu D, Peeters S, van der Salm A, van Loon J, de Ruysscher D, Nilsson R, Andersson S, Engwall E, Unipan M, Canters R.   +10 more
europepmc   +5 more sources

Synthetic computed tomography techniques for adaptive proton therapy in head and neck cancers. [PDF]

Phys Imaging Radiat Oncol
Head and neck (HN) radiotherapy often requires corrective interventions. This study evaluated three methods for synthetic computed tomography (CT) generation for adaptive HN planning using cone-beam CT (CBCT) images.
Kaushik S, Vatterodt N, Ödén J, Fredriksson A, Korreman SS, Toma-Dasu I.   +5 more
europepmc   +6 more sources

Dosimetric impact of adaptive proton therapy in head and neck cancer - A review. [PDF]

Clin Transl Radiat Oncol, 2023
Background: Intensity Modulated Proton Therapy (IMPT) in head and neck cancer (HNC) is susceptible to anatomical changes and patient set-up inaccuracies during the radiotherapy course, which can cause discrepancies between planned and delivered dose. The
Huiskes M, Astreinidou E, Kong W, Breedveld S, Heijmen B, Rasch C.   +5 more
europepmc   +6 more sources

Optically stimulated luminescence dosimeters for simultaneous measurement of point dose and dose-weighted LET in an adaptive proton therapy workflow. [PDF]

Front Oncol, 2023
PurposeTo demonstrate the suitability of optically stimulated luminescence detectors (OSLDs) for accurate simultaneous measurement of the absolute point dose and dose-weighted linear energy transfer (LETD) in an anthropomorphic phantom for experimental ...
Bobić M, Christensen JB, Lee H, Choulilitsa E, Czerska K, Togno M, Safai S, Yukihara EG, Winey BA, Lomax AJ, Paganetti H, Albertini F, Nesteruk KP.   +12 more
europepmc   +3 more sources

Comparing methods to improve cone-beam computed tomography for dose calculations in adaptive proton therapy. [PDF]

Phys Imaging Radiat Oncol
Background and purpose: Proton therapy requires dose monitoring, often performed based on repeated computed tomography (reCT) scans. However, reCT scans may not accurately reflect the internal anatomy and patient positioning during treatment.
Vestergaard CD, Vatterodt N, Elstrøm UV, Jensen K, Nørrevang O, Muren LP, Korreman SS, Taasti VT.   +7 more
europepmc   +3 more sources

Imaging, automation and workflow challenges for online adaptive proton therapy. [PDF]

Phys Imaging Radiat Oncol
Radiotherapy with protons has the potential to spare healthy tissue and reduce the integral dose compared with conventional photon-based radiotherapy. Still, the same peaked depth-dose profile that underpins this advantage makes proton treatments highly sensitive to anatomical changes, positioning variations and systematic uncertainties. To remain safe,
Wagenaar D, Albertini F, Muren LP, Knäusl B.   +3 more
europepmc   +6 more sources

Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer. [PDF]

Phys Imaging Radiat Oncol
Background and purpose: Although cone beam computed tomography (CBCT) enables online adaptive radiotherapy, its CT number accuracy may be insufficient for online adaptive proton therapy (OAPT). We compared proton dose distributions calculated directly on
Bobić M, Bushe DH, Lee H, Winey BA, Efstathiou JA, Paganetti H, Pursley J, Peters N, Nenoff L.   +8 more
europepmc   +3 more sources

Potential of automated online adaptive proton therapy to reduce margins for oesophageal cancer. [PDF]

Phys Imaging Radiat Oncol
Background and purpose:: Proton therapy for oesophageal cancer is administered over multiple fractions, based on a single pre-treatment image. However, anatomical changes can lead to the deterioration of the treatment plan, necessitating manual ...
Herbst P, Draguet C, Barragán-Montero AM, Villarroel EB, Vera MC, Populaire P, Haustermans K, Sterpin E.   +7 more
europepmc   +3 more sources

A planning approach for online adaptive proton therapy to cope with cone beam computed tomography inaccuracies. [PDF]

Phys Imaging Radiat Oncol
Background and purpose: In online-adaptive proton therapy planning based on cone beam computed tomography (CBCT), CT number errors can pose challenges. We propose an approach for coping with CT number uncertainties by increasing range robustness settings
Oud M, Breedveld S, Ng Wei Siang K, Cassetta R, Habraken S, Perkó Z, Heijmen B, Hoogeman M.   +7 more
europepmc   +3 more sources

Current status and upcoming developments for online adaptive proton therapy enabling a closed feedback loop for near real-time adaptation. [PDF]

Front Oncol
Proton therapy (PT) has the potential to deliver conformal doses to the tumor while sparing normal tissue, but is highly susceptible to treatment uncertainties. The occurrence of anatomical changes during PT treatments has a major impact on the delivered
Gambetta V, Stützer K, Richter C.
europepmc   +3 more sources