Results 1 to 10 of about 4,080,669 (137)

Clinical evaluation of synthetic computed tomography methods in adaptive proton therapy of lung cancer patients [PDF]

Physics and Imaging in Radiation Oncology, 2023
Background and purpose: Efficient workflows for adaptive proton therapy are of high importance. This study evaluated the possibility to replace repeat-CTs (reCTs) with synthetic CTs (sCTs), created based on cone-beam CTs (CBCTs), for flagging the need of
Vicki Trier Taasti, Djoya Hattu, Stephanie Peeters, Anke van der Salm, Judith van Loon, Dirk de Ruysscher, Rasmus Nilsson, Sebastian Andersson, Erik Engwall, Mirko Unipan, Richard Canters   +10 more
doaj   +4 more sources

Comparing methods to improve cone-beam computed tomography for dose calculations in adaptive proton therapy [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Proton therapy requires dose monitoring, often performed based on repeated computed tomography (reCT) scans. However, reCT scans may not accurately reflect the internal anatomy and patient positioning during treatment.
Casper Dueholm Vestergaard, Nadine Vatterodt, Ulrik Vindelev Elstrøm, Kenneth Jensen, Ole Nørrevang, Ludvig Paul Muren, Stine Sofia Korreman, Vicki Trier Taasti   +7 more
doaj   +3 more sources

Current status and upcoming developments for online adaptive proton therapy enabling a closed feedback loop for near real-time adaptation [PDF]

Frontiers in Oncology
Proton therapy (PT) has the potential to deliver conformal doses to the tumor while sparing normal tissue, but is highly susceptible to treatment uncertainties. The occurrence of anatomical changes during PT treatments has a major impact on the delivered
Virginia Gambetta, Virginia Gambetta, Kristin Stützer, Kristin Stützer, Christian Richter, Christian Richter, Christian Richter, Christian Richter   +7 more
doaj   +4 more sources

Optically stimulated luminescence dosimeters for simultaneous measurement of point dose and dose-weighted LET in an adaptive proton therapy workflow [PDF]

Frontiers in Oncology, 2023
PurposeTo demonstrate the suitability of optically stimulated luminescence detectors (OSLDs) for accurate simultaneous measurement of the absolute point dose and dose-weighted linear energy transfer (LETD) in an anthropomorphic phantom for experimental ...
Mislav Bobić, Mislav Bobić, Jeppe B. Christensen, Hoyeon Lee, Evangelia Choulilitsa, Evangelia Choulilitsa, Katarzyna Czerska, Michele Togno, Sairos Safai, Eduardo G. Yukihara, Brian A. Winey, Antony J. Lomax, Antony J. Lomax, Harald Paganetti, Francesca Albertini, Konrad P. Nesteruk   +15 more
doaj   +2 more sources

Dosimetric impact of adaptive proton therapy in head and neck cancer – A review [PDF]

Clinical and Translational Radiation Oncology, 2023
Background: Intensity Modulated Proton Therapy (IMPT) in head and neck cancer (HNC) is susceptible to anatomical changes and patient set-up inaccuracies during the radiotherapy course, which can cause discrepancies between planned and delivered dose. The
Merle Huiskes, Eleftheria Astreinidou, Wens Kong, Sebastiaan Breedveld, Ben Heijmen, Coen Rasch   +5 more
doaj   +2 more sources

Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Although cone beam computed tomography (CBCT) enables online adaptive radiotherapy, its CT number accuracy may be insufficient for online adaptive proton therapy (OAPT). We compared proton dose distributions calculated directly on
Mislav Bobić, Daniel H. Bushe, Hoyeon Lee, Brian A. Winey, Jason A. Efstathiou, Harald Paganetti, Jennifer Pursley, Nils Peters, Lena Nenoff   +8 more
doaj   +2 more sources

Facilitating MR-Guided Adaptive Proton Therapy in Children Using Deep Learning-Based Synthetic CT [PDF]

International Journal of Particle Therapy, 2021
Purpose: To determine whether self-attention cycle-generative adversarial networks (cycle-GANs), a novel deep-learning method, can generate accurate synthetic computed tomography (sCT) to facilitate adaptive proton therapy in children with brain tumors ...
Chuang Wang, PhD, Jinsoo Uh, PhD, Thomas E. Merchant, DO, PhD, Chia-ho Hua, PhD, Sahaja Acharya, MD   +4 more
doaj   +2 more sources

Online adaptive dose restoration in intensity modulated proton therapy of lung cancer to account for inter-fractional density changes

Physics and Imaging in Radiation Oncology, 2020
Background and purpose: In proton therapy, inter-fractional density changes can severely compromise the effective delivery of the planned dose. Such dose distortion effects can be accounted for by treatment plan adaptation, that requires considerable ...
Elena Borderías Villarroel, Xavier Geets, Edmond Sterpin   +2 more
doaj   +3 more sources

Potential of automated online adaptive proton therapy to reduce margins for oesophageal cancer [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose:: Proton therapy for oesophageal cancer is administered over multiple fractions, based on a single pre-treatment image. However, anatomical changes can lead to the deterioration of the treatment plan, necessitating manual ...
Pascal Herbst, Camille Draguet, Ana M. Barragán-Montero, Elena Borderías Villarroel, Macarena Chocan Vera, Pieter Populaire, Karin Haustermans, Edmond Sterpin   +7 more
doaj   +2 more sources

Trigger-based adaptive proton therapy and changes in target coverage and cardiac dose in esophageal cancer [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Inter-fractional anatomical variations during proton therapy for esophageal cancer may compromise target coverage and increase dose to surrounding organs.
Vlad Badiu, Esther Kneepkens, Dominique Reijtenbagh, Maaike Berbée, Richard Canters   +4 more
doaj   +2 more sources