Optically stimulated luminescence dosimeters for simultaneous measurement of point dose and dose-weighted LET in an adaptive proton therapy workflow [PDF]
Frontiers in Oncology, 2023 PurposeTo demonstrate the suitability of optically stimulated luminescence detectors (OSLDs) for accurate simultaneous measurement of the absolute point dose and dose-weighted linear energy transfer (LETD) in an anthropomorphic phantom for experimental ...
Mislav Bobić +15 more
doaj +2 more sources
Adaptive proton therapy. [PDF]
Phys Med Biol, 2021 Abstract Radiation therapy treatments are typically planned based on a single image set, assuming that the patient’s anatomy and its position relative to the delivery system remains constant during the course of treatment. Similarly, the prescription dose assumes constant biological dose-response over the treatment course.
Paganetti H, Botas P, Sharp GC, Winey B.
europepmc +3 more sources
Dosimetric impact of adaptive proton therapy in head and neck cancer – A review [PDF]
Clinical and Translational Radiation Oncology, 2023 Background: Intensity Modulated Proton Therapy (IMPT) in head and neck cancer (HNC) is susceptible to anatomical changes and patient set-up inaccuracies during the radiotherapy course, which can cause discrepancies between planned and delivered dose. The
Merle Huiskes +5 more
doaj +2 more sources
Clinical evaluation of synthetic computed tomography methods in adaptive proton therapy of lung cancer patients [PDF]
Physics and Imaging in Radiation Oncology, 2023 Background and purpose: Efficient workflows for adaptive proton therapy are of high importance. This study evaluated the possibility to replace repeat-CTs (reCTs) with synthetic CTs (sCTs), created based on cone-beam CTs (CBCTs), for flagging the need of
Vicki Trier Taasti +10 more
doaj +2 more sources
Facilitating MR-Guided Adaptive Proton Therapy in Children Using Deep Learning-Based Synthetic CT [PDF]
International Journal of Particle Therapy, 2021 Purpose: To determine whether self-attention cycle-generative adversarial networks (cycle-GANs), a novel deep-learning method, can generate accurate synthetic computed tomography (sCT) to facilitate adaptive proton therapy in children with brain tumors ...
Chuang Wang, PhD +4 more
doaj +2 more sources
Online daily adaptive proton therapy. [PDF]
Br J Radiol, 2020 It is recognized that the use of a single plan calculated on an image acquired some time before the treatment is generally insufficient to accurately represent the daily dose to the target and to the organs at risk. This is particularly true for protons, due to the physical finite range. Although this characteristic enables the generation of steep dose
Albertini F +4 more
europepmc +4 more sources
Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: Although cone beam computed tomography (CBCT) enables online adaptive radiotherapy, its CT number accuracy may be insufficient for online adaptive proton therapy (OAPT). We compared proton dose distributions calculated directly on
Mislav Bobić +8 more
doaj +2 more sources
Comparing methods to improve cone-beam computed tomography for dose calculations in adaptive proton therapy [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: Proton therapy requires dose monitoring, often performed based on repeated computed tomography (reCT) scans. However, reCT scans may not accurately reflect the internal anatomy and patient positioning during treatment.
Casper Dueholm Vestergaard +7 more
doaj +2 more sources
Potential of automated online adaptive proton therapy to reduce margins for oesophageal cancer [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose:: Proton therapy for oesophageal cancer is administered over multiple fractions, based on a single pre-treatment image. However, anatomical changes can lead to the deterioration of the treatment plan, necessitating manual ...
Pascal Herbst +7 more
doaj +2 more sources
A planning approach for online adaptive proton therapy to cope with cone beam computed tomography inaccuracies [PDF]
Physics and Imaging in Radiation OncologyBackground and purpose: In online-adaptive proton therapy planning based on cone beam computed tomography (CBCT), CT number errors can pose challenges. We propose an approach for coping with CT number uncertainties by increasing range robustness settings
Michelle Oud +7 more
doaj +2 more sources