Results 11 to 20 of about 3,973,865 (282)

Dosimetric comparison of autocontouring techniques for online adaptive proton therapy [PDF]

Physics in Medicine & Biology, 2023
Objective. Anatomical and daily set-up uncertainties impede high precision delivery of proton therapy. With online adaptation, the daily plan is reoptimized on an image taken shortly before the treatment, reducing these uncertainties and, hence, allowing
A. Smolders, E. Choulilitsa, K. Czerska, N. Bizzocchi, R. Krcek, A. Lomax, D. Weber, F. Albertini   +7 more
semanticscholar   +7 more sources

Feasibility of prompt gamma verification for cone-beam computed tomography-based online adaptive proton therapy. [PDF]

Phys Imaging Radiat Oncol
Highlights • Prompt-gamma imaging feasible for cone-beam CT-based online-adaptive proton therapy.• Adequate prompt-gamma simulations achieved for corrected cone-beam CT datasets.• Study investigated phantom as well as real world clinical head-and-neck ...
Bertschi S, Stützer K, Berthold J, Elstrøm U, Vestergaard A, Bernardini GP, Marmitt G, Janssens G, Pietsch J, Both S, Korreman S, Richter C.   +11 more
europepmc   +3 more sources

Deep learning-based 4D-synthetic CTs from sparse-view CBCTs for dose calculations in adaptive proton therapy. [PDF]

Med Phys, 2022
Background Time‐resolved 4D cone beam–computed tomography (4D‐CBCT) allows a daily assessment of patient anatomy and respiratory motion. However, 4D‐CBCTs suffer from imaging artifacts that affect the CT number accuracy and prevent accurate proton dose ...
Thummerer A, Seller Oria C, Zaffino P, Visser S, Meijers A, Guterres Marmitt G, Wijsman R, Seco J, Langendijk JA, Knopf AC, Spadea MF, Both S.   +11 more
europepmc   +3 more sources

Large anatomical changes in head-and-neck cancers - A dosimetric comparison of online and offline adaptive proton therapy. [PDF]

Clin Transl Radiat Oncol, 2023
Purpose: This work evaluates an online adaptive (OA) workflow for head-and-neck (H&N) intensity-modulated proton therapy (IMPT) and compares it with full offline replanning (FOR) in patients with large anatomical changes.
Bobić M, Lalonde A, Nesteruk KP, Lee H, Nenoff L, Gorissen BL, Bertolet A, Busse PM, Chan AW, Winey BA, Sharp GC, Verburg JM, Lomax AJ, Paganetti H.   +13 more
europepmc   +3 more sources

Retrospective analysis of adaptation frequencies and factors in offline in offline adaptive proton therapy. [PDF]

J Appl Clin Med Phys
Purpose/objective Offline adaptation is a standard practice in radiation therapy to adjust treatment plans for various reasons. Although offline adaptation in proton therapy has been addressed in prior studies, further research is still needed to clarify
Pak F, Zhang H, Hao Y, Schmidt M, Liu W, Schiff J, Laugeman E, Watts M, Perkins S, Zhao T.   +9 more
europepmc   +3 more sources

Adaptive proton therapy. [PDF]

Phys Med Biol, 2021
Abstract Radiation therapy treatments are typically planned based on a single image set, assuming that the patient’s anatomy and its position relative to the delivery system remains constant during the course of treatment. Similarly, the prescription dose assumes constant biological dose-response over the treatment course.
Paganetti H, Botas P, Sharp GC, Winey B.
europepmc   +3 more sources

Interfractional body surface monitoring using daily cone-beam computed tomography imaging for pediatric adaptive proton therapy. [PDF]

Phys Imaging Radiat Oncol
Highlights • A novel method detected tissue discrepancies per spot in the proton beam path.• The impact on plan quality was assessed based on water equivalent path length.• 5 mm change in body surface led to a drop in clinical target volume Dmin by 11.7 %
Ates O, Lee H, Uh J, Krasin MJ, Merchant TE, Hua CH.   +5 more
europepmc   +2 more sources

Partial adaptation for online-adaptive proton therapy triggered by during-delivery treatment verification: Feasibility study on prostate cancer treatments. [PDF]

Phys Imaging Radiat Oncol
Background and Purpose Online treatment verification during proton therapy delivery may detect deviations due to anatomical changes occurring along the treatment course and trigger immediate intervention, if necessary.
Gambetta V, Pieta V, Berthold J, Hölscher T, Fredriksson A, Richter C, Stützer K.   +6 more
europepmc   +2 more sources

Online daily adaptive proton therapy. [PDF]

Br J Radiol, 2020
It is recognized that the use of a single plan calculated on an image acquired some time before the treatment is generally insufficient to accurately represent the daily dose to the target and to the organs at risk. This is particularly true for protons, due to the physical finite range. Although this characteristic enables the generation of steep dose
Albertini F, Matter M, Nenoff L, Zhang Y, Lomax A.   +4 more
europepmc   +5 more sources

Time-saving potential of daily online adaptive proton therapy for head and neck cancers by reducing number of beams. [PDF]

Phys Imaging Radiat Oncol
Graphical ...
Choulilitsa E, Czerska K, Bachtiary B, Charles Weber D, John Lomax A, Albertini F.   +5 more
europepmc   +2 more sources