Results 11 to 20 of about 44,966 (284)

Current status and upcoming developments for online adaptive proton therapy enabling a closed feedback loop for near real-time adaptation [PDF]

Frontiers in Oncology
Proton therapy (PT) has the potential to deliver conformal doses to the tumor while sparing normal tissue, but is highly susceptible to treatment uncertainties. The occurrence of anatomical changes during PT treatments has a major impact on the delivered
Virginia Gambetta, Virginia Gambetta, Kristin Stützer, Kristin Stützer, Christian Richter, Christian Richter, Christian Richter, Christian Richter   +7 more
doaj   +2 more sources

Online adaptive dose restoration in intensity modulated proton therapy of lung cancer to account for inter-fractional density changes

Physics and Imaging in Radiation Oncology, 2020
Background and purpose: In proton therapy, inter-fractional density changes can severely compromise the effective delivery of the planned dose. Such dose distortion effects can be accounted for by treatment plan adaptation, that requires considerable ...
Elena Borderías Villarroel, Xavier Geets, Edmond Sterpin   +2 more
doaj   +3 more sources

Synthetic computed tomography techniques for adaptive proton therapy in head and neck cancers [PDF]

Physics and Imaging in Radiation Oncology
Head and neck (HN) radiotherapy often requires corrective interventions. This study evaluated three methods for synthetic computed tomography (CT) generation for adaptive HN planning using cone-beam CT (CBCT) images.
Suryakant Kaushik, Nadine Vatterodt, Jakob Ödén, Albin Fredriksson, Stine S. Korreman, Iuliana Toma-Dasu   +5 more
doaj   +2 more sources

Large anatomical changes in head-and-neck cancers – A dosimetric comparison of online and offline adaptive proton therapy [PDF]

Clinical and Translational Radiation Oncology, 2023
Purpose: This work evaluates an online adaptive (OA) workflow for head-and-neck (H&N) intensity-modulated proton therapy (IMPT) and compares it with full offline replanning (FOR) in patients with large anatomical changes.
Mislav Bobić, Arthur Lalonde, Konrad P. Nesteruk, Hoyeon Lee, Lena Nenoff, Bram L. Gorissen, Alejandro Bertolet, Paul M. Busse, Annie W. Chan, Brian A. Winey, Gregory C. Sharp, Joost M. Verburg, Antony J. Lomax, Harald Paganetti   +13 more
doaj   +2 more sources

Advances in proton therapy technology and global clinical applications [PDF]

Frontiers in Oncology
Proton therapy, by leveraging its unique physical characteristic of the Bragg peak, enables high-precision dose delivery to the tumor target while effectively protecting surrounding normal tissues, and has become an important representative of advanced ...
Qi Zhang, Wencui Yang, Lina Tan, Xiangyu Guo, Tao Wang, Pengfei Zhu, Zhouchen Jing, Lei Ma, Jun Hou   +8 more
doaj   +2 more sources

Clinical implementation and validation of an automated adaptive workflow for proton therapy

Physics and Imaging in Radiation Oncology, 2022
Background and purpose: Treatment quality of proton therapy can be monitored by repeat-computed tomography scans (reCTs). However, manual re-delineation of target contours can be time-consuming.
Vicki Trier Taasti, Colien Hazelaar, Femke Vaassen, Ana Vaniqui, Karolien Verhoeven, Frank Hoebers, Wouter van Elmpt, Richard Canters, Mirko Unipan   +8 more
doaj   +4 more sources

Commissioning an in-room mobile CT for adaptive proton therapy with a compact proton system. [PDF]

J Appl Clin Med Phys, 2018
AbstractPurposeTo describe the commissioning of AIRO mobile CT system (AIRO) for adaptive proton therapy on a compact double scattering proton therapy system.MethodsA Gammex phantom was scanned with varying plug patterns, table heights, and mAs on a CT simulator (CT Sim) and on the AIRO.
Oliver JA, Zeidan O, Meeks SL, Shah AP, Pukala J, Kelly P, Ramakrishna NR, Willoughby TR.   +7 more
europepmc   +3 more sources

Impact of reduced robustness settings on the necessity for proton therapy treatment plan adaptation in head-and-neck cancer patients [PDF]

Physics and Imaging in Radiation Oncology
Background and purpose: Robust optimization mitigates the effects of range and setup uncertainties in intensity–modulated proton therapy (IMPT) through robustness settings. However, it increases the dose to organs-at-risk (OARs).
Brian Zapien-Campos, Dirk Wagenaar, Tim Franssen, Hans Verbeek, Stefan Both, Peter Dendooven   +5 more
doaj   +2 more sources

Experimental validation of daily adaptive proton therapy [PDF]

Physics in Medicine & Biology, 2021
Abstract Anatomical changes during proton therapy require rapid treatment plan adaption to mitigate the associated dosimetric impact. This in turn requires a highly efficient workflow that minimizes the time between imaging and delivery. At the Paul Scherrer Institute, we have developed an online adaptive workflow, which is specifically ...
Lena Nenoff, Michael Matter, Marjolaine Charmillot, Serge Krier, Klara Uher, Damien Charles Weber, Antony John Lomax, Francesca Albertini   +7 more
openaire   +4 more sources

Proton Beam Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma [PDF]

International Journal of Particle Therapy, 2023
Purpose: To discuss the role of proton beam therapy (PBT) in the treatment of patients with oropharyngeal squamous cell carcinoma (OPSCC). Materials and Methods: A review of the pertinent literature. Results: Proton beam therapy likely results in reduced
William M. Mendenhall, MD, Jonathan J. Beitler, MD, MBA, Nabil F. Saba, MD, FACP, Ashok R. Shaha, MD, FACS, Sandra Nuyts, MD, PhD, Primož Strojan, MD, Heleen Bollen, MD, Oded Cohen, MD, Robert Smee, MD, Sweet Ping Ng, MD, Avraham Eisbruch, MD, Wai Tong Ng, MD, Jessica M. Kirwan, MA, Alfio Ferlito, MD, DLO, DPath, FRCSEd ad hominem, FRCS (Eng, Glasg, Ir) ad eundem, FDSRCS ad eundem, FACS, FHKCORL, FRCPath, FASCP, IFCAP   +13 more
doaj   +1 more source