Results 101 to 110 of about 25,449,411 (299)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synthetic Data for Fairness: Bias Mitigation in Facial Attribute Recognition

IEEE Open Journal of the Computer Society
Bias mitigation in soft facial attribute recognition remains a critical and underexplored challenge in the development of fair and accountable Artificial Intelligence (AI) systems.
Lucia Cascone, Marco Di Maio, Vincenzo Loia, Mattia Maucioni, Michele Nappi, Chiara Pero   +5 more
doaj   +1 more source

Replication Data for: Observation of wave amplification and temporal topological state in a non-synthetic photonic time crystal

This repository contains the data and code used for the analyses presented in the manuscript: "Observation of wave amplification and temporal topological state in a non-synthetic photonic time crystal.
Zou, Linyang
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Role of Synthetic Data and Generative AI in Breast Imaging: Promise, Pitfalls, and Pathways Forward

Diagnostics
Artificial intelligence is reshaping breast imaging, yet progress is constrained by data scarcity, privacy restrictions, and uneven representation.
Filippo Pesapane, Lucrezia D’Amelio, Luca Nicosia, Carmen Mallardi, Anna Bozzini, Lorenza Meneghetti, Gianpaolo Carrafiello, Enrico Cassano, Sonia Santicchia   +8 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Author Correction: Corruption of the Pearson correlation coefficient by measurement error and its estimation, bias, and correction under different error models

Scientific Reports, 2023
Edoardo Saccenti, Margriet H. W. B. Hendriks, Age K. Smilde   +2 more
doaj   +1 more source

Synthetic Scientific Image Generation with VAE, GAN, and Diffusion Model Architectures

Journal of Imaging
Generative AI (genAI) has emerged as a powerful tool for synthesizing diverse and complex image data, offering new possibilities for scientific imaging applications.
Zineb Sordo, Eric Chagnon, Zixi Hu, Jeffrey J. Donatelli, Peter Andeer, Peter S. Nico, Trent Northen, Daniela Ushizima   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source