Results 91 to 100 of about 2,406,574 (279)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Data hazards in synthetic biology
Synthetic BiologyAbstract Data science is playing an increasingly important role in the design and analysis of engineered biology. This has been fueled by the development of high-throughput methods like massively parallel reporter assays, data-rich microscopy techniques, computational protein structure prediction and design, and the development of whole ...
Natalie R Zelenka +9 more
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
IEEE AccessSynthetic data offers a compelling solution to the challenges associated with acquiring high-quality medical data, which is often constrained by privacy concerns and limited accessibility.
Abdullah Hosseini, Ahmed Serag
doaj +1 more source
Synthetic Data and Health Privacy
JAMAThis Viewpoint discusses generative artificial intelligence and safeguarding privacy by using synthetic data as a substitute for private health data.
Gwénolé Abgrall +2 more
openaire +3 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Computing OpenA speculator in the foreign exchange (Forex) market interacts in an environment where other participants as well as their strategies are unobserved. This constitutes a challenging interaction environment that generates complex time series data that may ...
Patrick Naivasha +3 more
doaj +1 more source
SEASAT synthetic-aperture radar data user's manual [PDF]
The SEASAT Synthetic-Aperture Radar (SAR) system, the data processors, the extent of the image data set, and the means by which a user obtains this data are described and the data quality is evaluated.
Held, D. N. +3 more
core +1 more source