Results 81 to 90 of about 1,035,049 (261)

The Role of Synthetic Data and Generative AI in Breast Imaging: Promise, Pitfalls, and Pathways Forward

Diagnostics
Artificial intelligence is reshaping breast imaging, yet progress is constrained by data scarcity, privacy restrictions, and uneven representation.
Filippo Pesapane, Lucrezia D’Amelio, Luca Nicosia, Carmen Mallardi, Anna Bozzini, Lorenza Meneghetti, Gianpaolo Carrafiello, Enrico Cassano, Sonia Santicchia   +8 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Synthetic Scientific Image Generation with VAE, GAN, and Diffusion Model Architectures

Journal of Imaging
Generative AI (genAI) has emerged as a powerful tool for synthesizing diverse and complex image data, offering new possibilities for scientific imaging applications.
Zineb Sordo, Eric Chagnon, Zixi Hu, Jeffrey J. Donatelli, Peter Andeer, Peter S. Nico, Trent Northen, Daniela Ushizima   +7 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Author Correction: Corruption of the Pearson correlation coefficient by measurement error and its estimation, bias, and correction under different error models

Scientific Reports, 2023
Edoardo Saccenti, Margriet H. W. B. Hendriks, Age K. Smilde   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Self-Supervised Learning Powered by Synthetic Data From Diffusion Models: Application to X-Ray Images

IEEE Access
Synthetic data offers a compelling solution to the challenges associated with acquiring high-quality medical data, which is often constrained by privacy concerns and limited accessibility.
Abdullah Hosseini, Ahmed Serag
doaj   +1 more source

How Protective Are Synthetic Data? [PDF]

, 2008
This short paper provides a synthesis of the statistical disclosure limitation and computer science data privacy approaches to measuring the confidentiality protections provided by fully synthetic data. Since all elements of the data records in the release file derived from fully synthetic data are sampled from an appropriate probability distribution ...
John M. Abowd, Lars Vilhuber
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source