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DNA Adduct-Directed Synthetic Nucleosides
Accounts of Chemical Research, 2019Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For example, O6-alkylguanine ( O6-alkylG) DNA adducts are strongly miscoding during DNA replication when the damaged nucleobase is a template for polymerase-mediated translesion DNA synthesis.
Michael H. Räz +3 more
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Binding of netropsin to DNA and synthetic polynucleotides
Molecular Biology Reports, 1974The interaction of netropsin with DNA and synthetic polydeoxyribonucleotides was studied by absorption spectrophotometry and circular dichroism. The results are consistent with a model in which a netropsin molecule occupies five base pairs in binding and carries three reaction sites each capable of interacting with one AT base pair.
A S, Zasedatelev +3 more
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Characterization of synthetic rabbit globin DNA
Archives of Biochemistry and Biophysics, 1973Abstract Synthetic DNA (cDNA) complementary to purified mRNA has already proven to be a useful hybridization probe for the quantitation of specific genes and for the detection of specific mRNAs in eukaryotic organisms. In view of its central role in such studies, it seemed necessary to characterize further one such cDNA and to determine the value of ...
J, Ross, H, Aviv, P, Leder
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NMR study of a synthetic DNA hairpin
Biochemistry, 1986The secondary structure of the synthetic oligodeoxyribonucleotide d(CGCGCGTTTTCGCGCG) (I) has been demonstrated to be a unimolecular hairpin structure (hairpin I) over a wide range of oligonucleotide concentrations (2 X 10(-5) to 1.6 X 10(-3) M) and temperature (0-87 degrees C).
S, Ikuta +4 more
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Circulating Tumor DNA in Advanced Solid Tumors: Clinical Relevance and Future Directions
Ca-A Cancer Journal for Clinicians, 2021Heather Parsons +2 more
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An Empirical Comparison of Preservation Methods for Synthetic DNA Data Storage
Small Methods, 2021Robert N. Grass +2 more
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Poly(ADP-Ribose) Polymerase (PARP) Inhibitors: Exploiting a Synthetic Lethal Strategy in the Clinic
Ca-A Cancer Journal for Clinicians, 2011Johann de Bono +2 more
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