Results 51 to 60 of about 169,227 (310)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applications [PDF]

, 2008
The rational design of novel triarylmethyl (trityl)-based mass tags (MT) for mass-spectrometric (MS) applications is described. We propose a "pKR+ rule" to correlate the stability of trityl carbocations with their MS performance: trityls with higher pKR+
Astakhova, Irina Kira, Astakhova, Irina V., Bernad, Pablo L., Khan, Safraz, Korshun, Vladimir A., Malakhov, Andrei D., Patel, Kaajal, Prokhorenko, Igor A., Shahgholi, Mona, Shchepinov, Mikhail S., Shmanai, Vadim V., Skorobogatyi, Mikhail V., Southern, Edwin M., Stepanova, Irina A., Ustinov, Alexey V.   +14 more
core   +2 more sources

Boranes in Organic Chemistry 1. О±-Carbonylalkyl- and ОІ-Oxyalkylboranes in Organic Synthesis

Eurasian Chemico-Technological Journal, 2002
This review is devoted to the synthesis of a-carbonylalkyl- and ОІ-hydroxy-alkyl boranes and their use in organic synthesis. a-Carbonyl-alkylboranes include several heteroatomic compounds, in particular, [1.2.3]-diazaborinines, uracyl boronic acids, and [
V.M. Dembitsky, G.A. Tolstikov, M. Srebnik   +2 more
doaj   +1 more source

Influence of Molecule Structure on Lightning Impulse Breakdown of Ester Liquids

Energies, 2021
Ester liquids are environmentally friendly insulating oils, and they can be used as an alternative to mineral oil in transformers, even though in most countries spills of ester oils must be treated like spills of mineral oil.
Huaqiang Li, Linfeng Xia, Shengwei Cai, Zhiqiang Huang, Jiaqi Li, Lisheng Zhong   +5 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Effect of Moisture and Aging of Kraft Paper Immersed in Mineral Oil and Synthetic Ester on Bubbling Inception Temperature in Power Transformers

Energies
Bubbling Inception Temperature (BIT) is a critical metric that indicates the temperature at which gas bubbles form due to cellulose decomposition in a paper–oil insulation system.
Ghada Gmati, Issouf Fofana, Patrick Picher, Oscar Henry Arroyo-Fernàndez, Djamal Rebaine, Fethi Meghnefi, Youssouf Brahami, Kouba Marie Lucia Yapi   +7 more
doaj   +1 more source

Expression and characterization of a cutinase (AnCUT2) from Aspergillus niger

Open Life Sciences, 2016
Cutin hydrolase (EC 3.1.1.74), an extracellular polyesterase found in pollens, bacteria and fungi, is an efficient catalyst that exhibits hydrolytic activity on a variety of water-soluble esters, synthetic fibers, plastics and triglycerides.
Ahmed Al-Tammar Khadijah, Omar Othman, Abdul Murad Abdul Munir, Abu Bakar Farah Diba   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Recent Advances in Homogeneous Metal-Catalyzed Aerobic C–H Oxidation of Benzylic Compounds [PDF]

, 2018
Csp(3)-H oxidation of benzylic methylene compounds is an established strategy for the synthesis of aromatic ketones, esters, and amides. The need for more sustainable oxidizers has encouraged researchers to explore the use of molecular oxygen.
Domínguez Pérez, Pilar Esther, Herrero Corral, María Teresa, San Martín Faces, Raúl, Urgoitia Gabikaetxebarria, Garazi   +3 more
core   +3 more sources