Results 121 to 130 of about 4,015,932 (307)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Synthetic Speech Discrimination using Pitch Pattern Statistics Derived from Image Analysis [PDF]

, 2012
In this paper, we extend the work by Ogihara, et al. to discriminate between human and synthetic speech using features based on pitch patterns. As previously demonstrated, significant differences in pitch patterns between human and synthetic speech can ...
Stewart, Bryan, Leon, Phillip L. De, Yamagishi, Junichi   +2 more
core  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Auxiliaries and Analyticity in Northwestern Bantu

Nordic Journal of African Studies
Northwestern Bantu (NWB) languages differ from Eastern/Southwestern Bantu languages in that their verb forms are more often analytic, with pre-stem inflectional material appearing in a complex that may be unbound from the main verb. This has resulted in
Elisabeth Kerr
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Transnational Governance of Synthetic Biology: Scientific uncertainty, cross-borderness and the ‘art’ of governance. For the Royal Society Science Policy Centre (UK). [PDF]

, 2011
Synthetic biology is a new field of research that aims to 'make biology easier to engineer'. Some claim that it could revolutionise biotechnology to deliver applications for the energy, medical and agricultural sectors. However there are concerns about
Zhang, Joy Yueyue, Rose, Nikolas, Rose, N., Marris, C., Marris, Claire, Zhang, J., Zhang, Joy Y.   +6 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Representing synthetic vs. analytic suffixation in Strict CV in English. Some problematic cases

Bucharest Working Papers in Linguistics, 2007
The aim of this paper is to present some additions and corrections to a model I proposed in an earlier article (Kristó 2006) concerning the formal distinction between analytic and non-analytic (synthetic) suffixation, couched in a Strict CV framework.
László Kristó
doaj  

Functional coexistence of synthetic and analytical future temporal forms in the present-day Germanic languages as a reflection of grammaticalization

Актуальні проблеми української лінгвістики: теорія і практика
The purpose of this article is to find out the reflection of joint functions of the synthetic future (when notional verbs are used  in the present tense form for future reference) and analytical future (when the combination of modal or inchoative verbs ...
Valeria Bondarenko, Andriy Botsman, Kateryna Karpova   +2 more
doaj   +1 more source