Results 271 to 280 of about 1,770,471 (326)

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, EarlyView.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +2 more sources

Synthetic lethality of EZH2 and DNMT Inhibition suppresses neuroblastoma proliferation via MYCN destabilization. [PDF]

BMC Cancer
Endo Y, Sugino RP, Takenobu H, Mukae K, Okada R, Shinno Y, Haruta M, Satoh S, Akter J, Hattori N, Nakazawa A, Ushijima T, Nakagawara A, Ohira M, Nio M, Kamijo T.   +15 more
europepmc   +1 more source

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

Exploiting replication stress for synthetic lethality in MYC-driven cancers. [PDF]

Am J Cancer Res
Zhang Y, Ye M, Luan X, Sun Z, Zhang WD.
europepmc   +1 more source

Benchmarking genetic interaction scoring methods for identifying synthetic lethality from combinatorial CRISPR screens. [PDF]

NAR Genom Bioinform
Ajmal H, Nandi S, Kebabci N, Ryan CJ.
europepmc   +1 more source

Targeting RAD51-BRCA2 Interaction to Enhance Synthetic Lethality with Olaparib in Pancreatic Cancer: Development of a Novel Phenyl Furan-Quinoline-Carboxylic Acid Series. [PDF]

ACS Med Chem Lett
Ferrandi G, Bagnolini G, Poppi L, Masi M, Previtali V, Andonaia A, Varignani G, Veronesi M, De Franco F, Falchi F, Di Stefano G, Girotto S, Roberti M, Cavalli A.   +13 more
europepmc   +1 more source

Enabling the study of gene function in gymnosperms: Virus‐induced gene silencing in Ephedra tweedieana

Applications in Plant Sciences, EarlyView.
Abstract Premise As the sister clade to angiosperms, extant gymnosperms are crucial for reconstructing ancestral gene regulatory networks in seed plants. This highlights the need for model systems representing each of their distinct lineages. However, tools to quickly and effectively investigate gene function in gymnosperms are still limited due to the
Anthony G. K. Garcia, Jo Trang Bùi, Todd P. Michael, Stefanie M. Ickert‐Bond, Verónica S. Di Stilio   +4 more
wiley   +1 more source

Z-scores outperform similar methods for analyzing CRISPR paralog synthetic lethality screens. [PDF]

Genome Biol
Chou J, Esmaeili Anvar N, Elghaish R, Chen J, Hart T.   +4 more
europepmc   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

The simultaneous targeted Inhibition of ISG15 and HMGCR disrupts cancer stemness through metabolic collapse and induces synthetic lethality in pancreatic ductal adenocarcinoma. [PDF]

J Exp Clin Cancer Res
Sun J, Wang JM, Zhang Q, Lin WY, Tang L, Lu SY, Li BQ, Du ZX, Wang HQ.   +8 more
europepmc   +1 more source