Results 281 to 290 of about 1,770,471 (326)

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Making teaching more attractive: Promising evidence of impact from Australia

British Educational Research Journal, EarlyView.
Abstract Sustaining teaching as a respected and attractive profession is more critical than ever, particularly as teachers' work becomes increasingly shaped by standardisation and accountability—conditions that have shown minimal positive impact while eroding the professional agency essential to job satisfaction.
Jennifer M. Gore, Sally Patfield, Leanne Fray, Andrew Miller, Brooke Rosser, Matthew Harper   +5 more
wiley   +1 more source

Concept of Synthetic Lethality in Cancer

World Journal of Dentistry, 2016
openaire   +1 more source

The Interplay of Dispersion and Thermal Shock in Pseudomonas Aeruginosa Biofilms

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Pathological bacterial biofilms formed on medical implants pose a significant challenge in clinical settings due to their resistance to antibiotics and the host immune response. Eradication of these biofilms by thermal shock has gained increasing attention as a means of eliminating these infections.
Hossein Zare, Josiah Power, Eric Nuxoll
wiley   +1 more source

Struct2SL: Synthetic lethality prediction based on AlphaFold2 structure information and Multilayer Perceptron. [PDF]

Comput Struct Biotechnol J
Huang Y, Yuan R, Li Y, Xing Z, Li J.
europepmc   +1 more source

Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers. [PDF]

Nat Commun
Chabanon RM, Shcherbakova L, Lacroix-Triki M, Aglave M, Zeghondy J, Kriaa V, Gougé A, Garrido M, Edmond E, Bigot L, Krastev DB, Brough R, Pettitt SJ, Thomas-Bonafos T, Samstein R, Massard C, Deloger M, Tutt AN, Barlesi F, Loriot Y, Delaloge S, Tawk M, Degerny C, Lin YL, Pistilli B, Pasero P, Lord CJ, Postel-Vinay S.   +27 more
europepmc   +1 more source

BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality. [PDF]

Genes Dev
Khalizieva A, Moser SC, Bouwman P, Jonkers J.   +3 more
europepmc   +1 more source

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma. [PDF]

Acta Neuropathol Commun
Lin B, Shelton AK, Smithberger E, Ziebro J, Skinner KR, Bash RE, Kirkman R, Stamper A, Butler M, Flores A, Angus SP, East MP, Cloughesy TF, Nathanson DA, Berens ME, Sarkaria JN, Binder ZA, O'Rourke DM, Howton TC, Lasseigne BN, Willey CD, Johnson GL, Hjelmeland AB, Furnari FB, Miller CR.   +24 more
europepmc   +1 more source

242 The concept of synthetic lethality

European Journal of Cancer Supplements, 2010
openaire   +1 more source

TARGET-SL: precision essential gene prediction using driver prioritisation and synthetic lethality. [PDF]

Brief Bioinform
Gillman R, Field MA, Schmitz U, Hebbard L.   +3 more
europepmc   +1 more source