Results 301 to 310 of about 1,770,471 (326)
Some of the next articles are maybe not open access.
MAGCN: A Multiple Attention Graph Convolution Networks for Predicting Synthetic Lethality
IEEE/ACM Transactions on Computational Biology & Bioinformatics, 2022Synthetic lethality (SL) is a potential cancer therapeutic strategy and drug discovery. Computational approaches to identify synthetic lethality genes have become an effective complement to wet experiments which are time consuming and costly.
Xinguo Lu +4 more
semanticscholar +1 more source
Synthetic lethality and beyond
Science Translational Medicine, 2016DNA damage–induced binding of DNA methyltransferases maximizes the efficacy of poly(ADP-ribose) polymerase inhibitors.
openaire +2 more sources
Synthetic Lethality in Cancer Therapeutics [PDF]
Annual Review of Cancer Biology, 2017 Treatment with targeted drugs has primarily focused on the genes and pathways that are mutated in cancer, which severely limits the repertoire of drug targets. Synthetic lethality exploits the notion that the presence of a mutation in a cancer gene is often associated with a new vulnerability that can be targeted therapeutically, thus greatly ...
Roderick L Beijersbergen +2 more
exaly +2 more sources
Synthetic Lethal Interactions in Cancer Therapy
Current Cancer Drug Targets, 2016Silencing of two or more complementary signaling pathways can lead to cell death, while loss of any single genetic function does not show a severe phnotype, this kind of inter action is coined as "synthetic lethality". Nowadays, synthetic lethality has become a widely used anti-cancer strategy.We reviewed the synthetic lethal interactions exploited in ...
Xinwei, Geng +3 more
openaire +2 more sources
Collateral lethality: A unique type of synthetic lethality in cancers
Pharmacology & TherapeuticsGenetic interactions play crucial roles in cell-essential functions. Intrinsic genetic defects in tumors typically involve gain-of- and loss-of-function mutations in tumor suppressor genes (TSGs) and oncogenes, respectively, providing potential antitumor vulnerabilities.
Zichen, Zhao +4 more
openaire +2 more sources
Synthetic lethality with cisplatin
Science Signaling, 2018Blocking the kinase MAST1 with lestaurtinib prevents cisplatin resistance in cancers driven by Raf-MEK signaling.
openaire +1 more source
A lethal combination for cancer cells: Synthetic lethality screenings for drug discovery
European Journal of Cancer, 2010In recent years, cancer drug discovery has faced the challenging task of integrating the huge amount of information coming from the genomic studies with the need of developing highly selective target-based strategies within the context of tumour cells that experience massive genome instability.
E. FERRARI, C. LUCCA, M. FOIANI
openaire +2 more sources
MYC, Metabolic Synthetic Lethality, and Cancer
2016The MYC oncogene plays a pivotal role in the development and progression of human cancers. It encodes a transcription factor that has broad reaching effects on many cellular functions, most importantly in driving cell growth through regulation of genes involved in ribosome biogenesis, metabolism, and cell cycle.
Annie L, Hsieh, Chi V, Dang
openaire +2 more sources
A (synthetic) lethal weapon for cancer
Science Translational Medicine, 2018ROS1 inhibition in E-cadherin–deficient tumors leads to synthetic lethality, which could be exploited for the selective treatment of breast cancer patients.
openaire +1 more source