Results 71 to 80 of about 889,368 (297)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
AIP Advances, 2023 Data-driven deep learning models are emerging as a promising method for characterizing pore-scale flow through complex porous media while requiring minimal computational power. However, previous models often require extensive computation to simulate flow
Danny D. Ko, Hangjie Ji, Y. Sungtaek Ju
doaj +1 more source
A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]
, 2019 Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan +4 more
core +2 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Design som medievitenskapelig metode
Norsk Medietidsskrift, 2012 The author argues that design of media technologies, media genres and media texts should be an important part of media studies. Design methods in media studies compared to methods in sciences, especially computer science, can yield important results if ...
Anders Fagerjord
doaj +1 more source
2D-to-3D facial expression transfer [PDF]
, 2018 © 20xx IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new ...
Agudo Martínez, Antonio +3 more
core +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Ready or not, here I come. How synthetic media challenge epistemic institutions
Studies in Communication, MediaThis editorial examines how synthetic media and deepfakes unsettle the epistemic foundations of contemporary public communication. We outline how rapidly advancing generative technologies erode long-standing assumptions about the authenticity of visual ...
Alexander Godulla +1 more
doaj +1 more source
Non-Abelian gauge field optics
Nature Communications, 2019 In optics, schemes have been proposed to realize synthetic gauge fields, but are restricted to the Abelian type. Here, the authors demonstrate synthetic SU(2) non-Abelian gauge fields in anisotropic media, which allows the study of novel optical ...
Yuntian Chen +6 more
doaj +1 more source