Results 71 to 80 of about 884,751 (294)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Survey on the use of synthetic Food Colors in Food Samples procured from different educational institutes of Karachi city [PDF]

, 2013
The present study was carried out to find the type of food colors added to various food products especially those vended at or near different educational institutes of Karachi city.
Nida Saleem, Seema Ismat khan, Zahida Nasreen Umar   +2 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Design som medievitenskapelig metode

Norsk Medietidsskrift, 2012
The author argues that design of media technologies, media genres and media texts should be an important part of media studies. Design methods in media studies compared to methods in sciences, especially computer science, can yield important results if ...
Anders Fagerjord
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Ready or not, here I come. How synthetic media challenge epistemic institutions

Studies in Communication, Media
This editorial examines how synthetic media and deepfakes unsettle the epistemic foundations of contemporary public communication. We outline how rapidly advancing generative technologies erode long-standing assumptions about the authenticity of visual ...
Alexander Godulla, Christian Pieter Hoffmann   +1 more
doaj   +1 more source

Non-Abelian gauge field optics

Nature Communications, 2019
In optics, schemes have been proposed to realize synthetic gauge fields, but are restricted to the Abelian type. Here, the authors demonstrate synthetic SU(2) non-Abelian gauge fields in anisotropic media, which allows the study of novel optical ...
Yuntian Chen, Ruo-Yang Zhang, Zhongfei Xiong, Zhi Hong Hang, Jensen Li, Jian Qi Shen, C. T. Chan   +6 more
doaj   +1 more source

A synthetic medium to simulate sugarcane molasses

Biotechnology for Biofuels, 2018
Background Developing novel microbial cell factories requires careful testing of candidates under industrially relevant conditions. However, this frequently occurs late during the strain development process.
Felipe Senne de Oliveira Lino, Thiago Olitta Basso, Morten Otto Alexander Sommer   +2 more
doaj   +1 more source