The Cross-Talk between Spirochetal Lipoproteins and Immunity [PDF]
Spirochetal diseases such as syphilis, Lyme disease and leptospirosis are major threats to public health. However the immunopathogenesis of these diseases has not been fully elucidated.
Akins +222 more
core +3 more sources
Middle ear tuberculosis: Diagnostic criteria [PDF]
Introduction. Tuberculous otitis is a diagnostic problem due to the difficulty to obtain microbiological, histomorphological and cytological confirmation of the disease. Objective. Our objective was to compare clinical and radiological characteristic and
Dudvarski Zoran +6 more
core +1 more source
Syphilis is a multistage chronic sexually transmitted infection caused by the spirochete Treponema pallidum subsp. pallidum (T. pallidum). Today, syphilis is still endemic in low- and middle-income nations and has become resurgent in many high-income ...
Austin M. Haynes +9 more
doaj +1 more source
Antigenic Conservation of an Immunodominant Invariable Region of the VlsE Lipoprotein among European Pathogenic Genospecies of Borrelia burgdorferi SL [PDF]
Lyme disease is caused by genetically divergent spirochetes, including 3 pathogenic genospecies: Borrelia burgdorferi sensu stricto, B. garinii, and B. afzelii. Serodiagnosisis complicated by this genetic diversity. A synthetic peptide (C6), based on the
Aberer, Elisabeth +9 more
core
Multicenter evaluation of the Elecsys Toxo IgG and IgM tests for the diagnosis of infection with Toxoplasma gondii [PDF]
Detection of IgG and IgM antibodies is commonly performed for the diagnosis of infection with Toxoplasma gondii. We determined the accuracy of the Elecsys Toxo IgG and IgM test at four European laboratories compared to local reference methods ...
Liesenfeld,, Meylan,, Paris,
core +1 more source
Acroangiodermatitis (pseudo-Kaposi's sarcoma) in an HIV sero-positive patient with syphilis and hepatitis C virus coinfection: clinical and dermatopathological features [PDF]
Acroangiodermatitis is an angioproliferative disease usually related to chronic venous insufficiency, and it is considered a clinical and histological simulator of Kaposi's sarcoma (KS).
Fred Bernardes Filho +4 more
doaj +2 more sources
Diagnostically significant antigens of Treponema pallidum subsp. pallidum: identification, serological efficacy, and characterisation of the major antigenic determinants. [PDF]
The antibody response to native antigens derived from Treponema pallidum (Nichols strain) was investigated by western blotting. In early primary disease the responses were most frequently to the major immunodominant antigen, TpN47, and the flagellar ...
Grace, Christopher
core +1 more source
Background: The lack of Treponema pallidum-specific antigens with highly accurate diagnosis makes the diagnosis of syphilis challenging. Methods: A soluble recombinant version of a new diagnostic protein Tp0663 has been produced.
Man Xu +11 more
doaj +1 more source
Treponemal Specific Tests for the Serodiagnosis of Syphilis
To determine the rate of concordance of the Microhemagglutination Assay for Antibodies to T. pallidum (MHA-TP) and the Fluorescent Treponemal Antibody-Absorption test (FTA-ABS) prior to therapy in patients with early stage syphilis and to assess the incidence of and associated risk factors for seroreversion of these treponemal specific tests during the
Michael Augenbraun +4 more
openalex +4 more sources
Borrelia Burgdorferi-specific IgA in Lyme Disease [PDF]
The laboratory diagnosis of Lyme disease is currently dependent on the detection of IgM and IgG antibodies against Borrelia burgdorferi, the causative agent of the disease. The significance of serum IgA against B. burgdorferi remains unclear.
Arnaboldi, Paul +2 more
core +3 more sources

