Results 121 to 130 of about 38,900 (274)

Lifting the Burden of Addiction: Philanthropic Opportunities to Address Substance Use Disorders in the United States [PDF]

, 2015
Substance use disorders (SUDs), also known as substance abuse or addiction, affect an estimated 20 million or more adolescents and adults in the U.S. This guidance provides philanthropic funders with the tools & information to reduce immediate harm from ...
Cecily Wallman-Stokes, Götz Bechtolsheimer, Jacob Appel, Jennifer Gable, Jessica Chiu, Katherina Rosqueta, Rebecca Hobble   +6 more
core  

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

A Scoping Review on the Effects of COVID-19 on Syringe Service Programs in the United States. [PDF]

Cureus, 2023
Pietrantoni D, Barroca C, Lynch S, Byrne J, Ortner M, Kotwani R, Limbrick K, Kaldas P, Moussa M, Fredrickson T, Schaefer J, Jacobs RJ.   +11 more
europepmc   +1 more source

Public Health Outcomes as a Measure of Efficacy of Syringe Exchange Programs [PDF]

, 2017
Introduction. A syringe exchange is a public health intervention that offers nonjudgmental services to intravenous drug users (IVDU), providing clean syringes in exchange for used syringes.
Corse, Andrew, Donaldson, Katelyn, Gallagher, Andrew, Jacobsen, Peter, Larrabee, Jerry, Li, Anita, Pratt, Morgan R, Smith, Benjamin F., Tajik, Amelia V., Vezina, T.   +9 more
core   +1 more source

Photothermal Transport for Guiding Nanoparticles Through the Vitreous Humor

Advanced Science, EarlyView.
Nanosecond laser irradiation of the clinically approved dye indocyanine green (ICG) enables light‐guided nanoparticle transport within the vitreous humor. The combined use of ICG and pulsed laser illumination induces localized convection and thermophoresis, directing particles toward illuminated regions.
Léa Guerassimoff, Yera Ussembayev, Louise De Clerck, Deep Punj, Martijn van den Broek, Filip Beunis, Katrien Remaut, Kevin Braeckmans, Stefaan C. De Smedt, Félix Sauvage   +9 more
wiley   +1 more source

Healthcare Seeking Behavior's Trend of Family Planning In Indonesia [PDF]

, 2017
Community participation in programs of Family Planning is determined by health se rvice seeking behaviour, so the Ministry must be ensured the availability of family planning affordability, acceptability and quality of service. Hence
Afridah, Wiwik, Firdausi, Nurul Jannatul
core  

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Bringing HIV Prevention to Scale: An Urgent Global Priority [PDF]

, 2007
Illustrates the need for a scaled-up HIV prevention response in order to stem the epidemic, describes impediments to HIV prevention efforts and examples of successful initiatives, and includes recommendations for governments, health agencies, and ...

core  

Updates on syringe coverage and service uptake among needle and syringe programs in the United States, 2019–2020

International Journal of Drug Policy
As injection drug use has increased in the US, so too has the prevalence of receptive syringe sharing. Since the 1980s, Needle and Syringe Programs (NSPs) have been an important source of clean injection equipment and disposal of used syringes. This study reports national syringe coverage and examines the impact of program attributes on organizational ...
Hansel E. Tookes, Tyler S. Bartholomew, Sabrina E. Soto Sugar, Marina D. Plesons, Ricky N. Bluthenthal, Lynn D. Wenger, Sheila V. Patel, Alex H. Kral, Barrot H. Lambdin   +8 more
openaire   +2 more sources