Results 151 to 160 of about 38,900 (274)

Ingenuity and resiliency of syringe service programs on the front lines of the opioid overdose and COVID-19 crises. [PDF]

open access: yesTransl Res, 2021
Wenger LD   +5 more
europepmc   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai   +7 more
wiley   +1 more source

Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of STXBP1‐Related Epileptic Encephalopathy

open access: yesAnnals of Neurology, EarlyView.
Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang   +7 more
wiley   +1 more source

Unlocking fruit dimensions: Quantification of functional traits driving plant–frugivore interactions

open access: yesApplications in Plant Sciences, EarlyView.
Abstract Fleshy fruits attract animals to ingest fruit, swallow the seeds, and release them in the landscape, thus facilitating seed dispersal and plant regeneration. Attraction of animal dispersers is achieved via attractants such as color or scent, and rewards like sugars, lipids, and micronutrients.
Linh M. N. Nguyen   +4 more
wiley   +1 more source

Improved sample management in the cylindrical-tube microelectrophoresis method [PDF]

open access: yes
A modification to an analytical microelectrophoresis system is described that improves the manipulation of the sample particles and fluid. The apparatus modification and improved operational procedure should yield more accurate measurements of particle ...
Smolka, A. J. K.
core   +1 more source

Lab‐Scale Continuous Biomanufacturing: A Tool for Process Development With Adaptive Strategies for Capture and Virus Inactivation

open access: yesBiotechnology and Bioengineering, EarlyView.
Schematic representation of the continuous lab‐scale process. ABSTRACT Monoclonal antibodies (mAbs) are nowadays fundamental in treating a wide range of severe diseases, including cancer, infections, or autoimmune disorders. Due to their high specificity, potent activity, and fewer side effects compared to small molecular drugs, the market for mAbs is ...
Thomas Kruse   +5 more
wiley   +1 more source

Evaluating Isochoric Freezing as a Strategy for Storage of Red Blood Cells

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Red blood cells (RBCs) are needed for life‐saving blood transfusions, but they undergo continuous degradation during storage. Preserving RBCs for clinical transfusion remains a challenge due to storage‐induced damage and limitations of traditional freezing methods.
Yuanheng Zhao   +3 more
wiley   +1 more source

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