Results 151 to 160 of about 633,595 (269)

Photothermal Transport for Guiding Nanoparticles Through the Vitreous Humor

Advanced Science, EarlyView.
Nanosecond laser irradiation of the clinically approved dye indocyanine green (ICG) enables light‐guided nanoparticle transport within the vitreous humor. The combined use of ICG and pulsed laser illumination induces localized convection and thermophoresis, directing particles toward illuminated regions.
Léa Guerassimoff, Yera Ussembayev, Louise De Clerck, Deep Punj, Martijn van den Broek, Filip Beunis, Katrien Remaut, Kevin Braeckmans, Stefaan C. De Smedt, Félix Sauvage   +9 more
wiley   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Proven HIV Prevention Strategies [PDF]

, 2009
Describes strategies that, used in combination, have proven to be effective in preventing sexual, blood-borne, and mother-to-child transmission of HIV.

core  

Updates on syringe coverage and service uptake among needle and syringe programs in the United States, 2019–2020

International Journal of Drug Policy
As injection drug use has increased in the US, so too has the prevalence of receptive syringe sharing. Since the 1980s, Needle and Syringe Programs (NSPs) have been an important source of clean injection equipment and disposal of used syringes. This study reports national syringe coverage and examines the impact of program attributes on organizational ...
Hansel E. Tookes, Tyler S. Bartholomew, Sabrina E. Soto Sugar, Marina D. Plesons, Ricky N. Bluthenthal, Lynn D. Wenger, Sheila V. Patel, Alex H. Kral, Barrot H. Lambdin   +8 more
openaire   +2 more sources

All‐PEG‐Like Block Copolymers Self‐Assemble into Stealth Nanocarriers for Drug Delivery

Advanced Science, EarlyView.
Self‐assembling nanoparticles composed entirely of POEGMA are engineered by exploiting side‐chain–dependent amphiphilicity and tunable thermoresponsive behavior. These single‐material nanocarriers encapsulate diverse hydrophobic drugs with high efficiency, retain therapeutic activity, improve in vivo efficacy, and evade anti‐PEG antibodies.
Parul Sirohi, Brooke E. Silverstein, Yulia Shmidov, Sonal Deshpande, Joy Tong, Yvonne Y. Ma, Chinmay S. Potnis, Soumen Saha, Xinghai Li, Max R. Ney, Sarah Y. Kim, Joshua J. Milligan, Lixin Fan, Matthew L. Becker, Daniel Reker, Ashutosh Chilkoti   +15 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
Machine learning models predict in real time the onset of harmful microbubble collapse during microbubble‐enhanced focused ultrasound (MB‐FUS) and enable dynamic adjustment of sonication to prevent cavitation‐induced damage. This predictive control expands the safe operating window for bloodbrain barrier opening, enhancing nanoparticle delivery and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications [PDF]

, 2019
Microfluidic devices allow for the manipulation of fluids, particles, cells, micro-sized organs or organisms in channels ranging from the nano to submillimeter scales. A rapid increase in the use of this technology in the biological sciences has prompted
Juan, Jonathan, Kavanagh, Anthony, Levis, Megan, Ontiveros, Fernando, Zartman, Jeremiah J.   +4 more
core   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Controlling Newcastle Disease in Village Chickens: A Field Manual [PDF]

Livestock Production/Industries,
Anonymous, Spradbrow, Peter B.
core   +1 more source