Results 21 to 30 of about 73,169 (257)

Examining unsafe injection practices associated with auto-disable (AD) syringes: a systematic review

Human Vaccines & Immunotherapeutics, 2021
Auto-disable (AD) syringes are specifically designed to prevent syringe reuse. However, the notion that specific AD syringe designs may be unsafe due to reuse concerns related to the syringe’s activation point has surfaced.
Anokhi Ali Khan, Mehr Munir, Fatima Miraj, Shayan Imran, Danya Arif Siddiqi, Arshad Altaf, Aamir Javed Khan, Subhash Chandir   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A national physician survey on prescribing syringes as an HIV prevention measure

Substance Abuse Treatment, Prevention, and Policy, 2009
Background Access to sterile syringes is a proven means of reducing the transmission of human immunodeficiency virus (HIV), viral hepatitis, and bacterial infections among injection drug users. In many U.S.
Macalino GE, Sachdev D Dhawan, Rich JD, Becker C, Tan LJ, Beletsky L, Burris S   +6 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

In vitro assessment of needle and irrigant penetration when using different irrigation needle tips

Biomaterial Investigations in Dentistry
Objective: The aim of this study was to compare the needle and irrigant penetration depth of a newly developed multi-vented polymer needle (30G), with three established needle designs – an open-ended metal needle (30G), a side-vented polymer needle (30G)
Saleha Hussain, Lars Bjørndal, Merete Markvart   +2 more
doaj   +1 more source

A protocol for microbiologically safe preparation, storage, and use of autologous serum eye-drops in low-income countries

Journal of Infection in Developing Countries, 2015
Introduction: The study aimed to investigate whether the preparation, storage, and use of autologous serum in insulin syringes is microbiologically safe. Methodology: Blood samples (10 mL) were obtained from 10 volunteers.
Francesco Blasetti, Donatella Usai, Salvatore Sotgia, Ciriaco Carru, Stefania Zanetti, Antonio Pinna   +5 more
doaj   +1 more source

Safer Enteral Nutrition Syringes

Patient Safety, 2020
Hundreds of thousands of patients receive enteral nutrition (EN) or tube feeding each year in U.S. hospitals, and many more in long-term care and home settings.
Peggi Guenter, Beth Lyman
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimal provision of opiate substitution therapy and needle and syringe programmes: a multi-method realist evaluation

Health Technology Assessment
Background The barriers and facilitators to engagement with Opiate Substitute Treatment and Needle and Syringe Provision need to be better understood to develop interventions to attract people into services.
Peter McCulloch, April Shaw, Gail Gilchrist, Catriona Matheson, Margaret Maxwell, Joanne Neale, Gareth Myring, Hugh McLeod, Matt Hickman, Peter Vickerman, Alison Munro, Steve MacGillivray   +11 more
doaj   +1 more source