Results 131 to 140 of about 28,979,637 (350)

A bright future for system dynamics: From art to computational science and beyond

, 2012
This paper presents a bright future for quantitative System Dynamics Modeling. This future relates to all major issues and grand challenges which all happen to be dynamically complex and deeply uncertain.
Kwakkel, J.H. (author), Pruyt, E. (author), Kwakkel, J.H., Pruyt, E.   +3 more
core  

Dynamics Simulation of Remotely Operated Vehicle-Fiber Optic Micro Cable System

, 2008
Li Q, Xu H, Zhang Q, Wang X, Li ZG. Dynamics Simulation of Remotely Operated Vehicle-Fiber Optic Micro Cable System.
Li, ZhiGang, Li ZG(李智刚), Xu, Hongli, Zhang QF(张奇峰), Qiang Li, Li, Qiang ; https://orcid.org/, Wang, Xiaohui, Xiaohui Wang, Zhigang Li, Wang XH(王晓辉), Hongli Xu, Qifeng Zhang, Zhang, Qifeng, Li Q(李强), Xu HL(徐红丽)   +14 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Logical Dynamics and Dynamical Systems.

, 2018
This thesis is on information dynamics modeled using *dynamic epistemic logic* (DEL). It takes the simple perspective of identifying models with maps, which under a suitable topology may be analyzed as *topological dynamical systems*. It is composed of an introduction and six papers.
openaire   +1 more source

Using Difference Equation to Model Discrete-time Behavior in System Dynamics Modeling

, 2014
In system dynamics modeling, differential equations have been used as the basic mathematical operator. Using difference equation to build system dynamics models instead of differential equation, can be insightful for studying small organizations or ...
Ghorbani, A., Hesan, R. (author), Ghorbani, A. (author), Hesan, R., Dignum, M.V. (author), Dignum, M.V.   +5 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Electrical impedance-based tissue classification for bladder tumor differentiation

Scientific Reports
Including sensor information in medical interventions aims to support surgeons to decide on subsequent action steps by characterizing tissue intraoperatively.
Carina Veil, Franziska Krauß, Bastian Amend, Falko Fend, Oliver Sawodny   +4 more
doaj   +1 more source

Adaptive robust greenhouse climate control: Combining deep reinforcement learning and economic optimization

Smart Agricultural Technology
Climate control in semi-closed greenhouses is essential for maximizing crop yield and ensuring energy-efficient operation. Model Predictive Control (MPC) is widely used to optimize control inputs based on system dynamics and operational constraints ...
Mohamed Mansour, Kiran Kumar Sathyanarayanan, Philipp Sauerteig, Stefan Streif   +3 more
doaj   +1 more source

Dynamics of Fiscal Space and Debt Sustainability in Macrosystem

Тези доповiді учасника Міжнародної науково-практичної конференції "Proceedings of the 2024 International System Dynamics Conference", Bergen, August 4-8 ...
Hryhoriev, Hennadii
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source