Results 121 to 130 of about 32,200,596 (338)

Road Maps: a guide to learning system dynamics [PDF]

, 1995
MIT System Dynamics Education Project developed Road Maps, a series of self-guides, modeling and selected literature to help students and teachers learn the principles of system dynamics.

core   +1 more source

Exploring agricultural production systems and their fundamental components with system dynamics modelling

, 2016
Agricultural production in the United States is undergoing marked changes due to rapid shifts in consumer demands, input costs, and concerns for food safety and environmental impact.
J. Walters, D. Archer, G. Sassenrath, J. Hendrickson, J. Hanson, J. Halloran, P. Vadas, V. J. Alarcon   +7 more
semanticscholar   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transfer Matrix Method for the Analysis of Multiple Natural Frequencies

Mathematics
Multiple natural frequencies may be encountered when analyzing the essential natural vibration of a symmetric mechanical system or sub-structure system or a system with special parameters.
Jinghong Wang, Xiaoting Rui, Bin He, Xun Wang, Jianshu Zhang, Kai Xie   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Investigations into wastewater composition focusing on nonwoven wet wipes

Technical Transactions, 2017
This paper summarizes the problems caused for wastewater systems by changing wastewater composition, especially the increasing use of nonwoven wet wipes and their disposal via the toilet.
Mitchell Raja-Louisa, Thamsen Paul Uwe, Gunkel Michel, Waschnewski Jan   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Launch dynamics modeling and simulation of box-type multiple launch rocket system considering plane clearance contact

Defence Technology
As the performance of the box-type multiple launch rocket system (BMLRS) improves, its mechanical structures, particularly the plane clearance design between the slider on the rocket and the guide inside the launch canister, have grown increasingly ...
Jinxin Tang, Guoping Wang, Genyang Wu, Yutian Sun, Lilin Gu, Xiaoting Rui   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Contact mechanics and friction: Role of adhesion

Friction
This paper presents an overview of the role of adhesion in various tribological phenomena. We discuss (1) adhesion and adhesive hysteresis in rough contacts, (2) adhesive contribution to dry friction, (3) properties of adhesive contacts under tangential ...
Valentin L. Popov, Qiang Li, Iakov A. Lyashenko   +2 more
doaj   +1 more source