Results 201 to 210 of about 28,979,637 (350)

Editorial: System dynamics modeling in public health: implementations and implications. [PDF]

Front Public Health
Jinnett K, Lounsbury DW, Sabounchi NS, Lebcir R, Brereton CF.   +4 more
europepmc   +1 more source

Using System Dynamics to Explore the Water Supply and Demand Dilemmas of a Small South African Municipality

, 2014
This paper explores the challenges faced by small municipalities in providing water services in a developing-world context of increasing urban demand. The paper uses a case study of the Sundays River Valley Municipality (SRVM) in South Africa.
Palmer, C.G. (author), Brent, A.C. (author), Musango, J.K., Brent, A.C., Clifford Holmes, J.K., Musango, J.K. (author), Slinger, J.H. (author), Palmer, C.G., Clifford Holmes, J.K. (author), Slinger, J.H.   +9 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Structure and Dynamics of the Residential Building Environment: What Mechanisms Determine the Development of the Building Stock?

, 2007
Grösser, Stefan N., Ulli-Beer, Silvia
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Hydrothermal system dynamics at Pisciarelli fumarole field (Campi Flegrei): insights from geophysical and numerical modelling. [PDF]

Sci Rep
Salone R, Troiano A, Di Giuseppe MG, Isaia R, Di Maio R.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Optimization of echinococcosis control measures based on system dynamics. [PDF]

PLoS Comput Biol
Ma J, Liu X, He Z, Zhang H, Ma Y, Fan Z, Zhao X, Zhi J, Cao Q, Xue H, Gou H.   +10 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source