Results 191 to 200 of about 136,148 (315)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

System Dynamics Modelling of Credit Risk Management

, 2018
Proceedings of the 1st Research Conference "Conference System Dynamics Modeling for Public and Corporate Finance: Background and Opportunities" (December 10, 2018 Kyiv, Ukraine)
Kaminskyi, Andrii
core  

Qualitative system dynamics modelling to support the design and implementation of tuberculosis infection prevention and control measures in South African primary healthcare facilities. [PDF]

Health Policy Plan
Diaconu K, Karat A, Bozzani F, McCreesh N, Falconer J, Voce A, Vassall A, Grant AD, Kielmann K.   +8 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

System Dynamics Modelling in Teaching Economics

, 2018
Proceedings of the 1st Research Conference "Conference System Dynamics Modeling for Public and Corporate Finance: Background and Opportunities" (December 10, 2018 Kyiv, Ukraine)
Dadashova, Pervin
core  

Together, taking the next step: using system dynamics modelling to build community renewable energy programmes in Aotearoa New Zealand. [PDF]

J R Soc N Z
Roberts R, Brent A, Hinkley JJ, Cavana RY.   +3 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Factors for winning Format Battles: A modelling approach

, 2014
There is considerable literature on format competition with several review articles establishing lists of factors that are thought to apply broadly in such contexts.
Van de Kaa, G. (author), Van de Kaa, G., Papachristos, G. (author), Papachristos, G.   +3 more
core  

Dealing with soft variables and data scarcity: lessons learnt from quantification in a participatory system dynamics modelling process. [PDF]

Syst Dyn Rev
Pluchinotta I, Zhou K, Zimmermann N.
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source