Results 181 to 190 of about 136,148 (315)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Increasing timely access to evidence-based treatment for opioid use disorder using novel digital health and system dynamics modelling approaches: a study protocol. [PDF]

BMJ Open
Canty T, S Sabounchi N, Heimer R, Pantalon M, Ryus C, Buchanan L, Grewal M, Maffei J, D'Onofrio G, Heckmann R.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

System Dynamics Framework for Sustainable Development Analysis of Local Governments

This article presents a concept and theoretical specification for a system dynamics based framework for sustainable development analysis of local governments. Although many countries in the world aspire to the principles of sustainable development, there
Lektauers, Arnis
core  

Revealed: The Underlying Flow, Masked by Predictive Risk Tools but Uncovered by Dynamic Simulation used in Joint Commissioning

International Journal of Integrated Care, 2015
Douglas McKelvie, Steve Arnold, Terry Dafter   +2 more
doaj   +3 more sources

Optimal control strategies supported by system dynamics modelling: a study on hookworm disease in China. [PDF]

Infect Dis Poverty
Zhu H, Zheng J, Huang J, Zhang M, Zhou C, Zhu T, Tian H, Wu X, Liu Y, Zhong B, Xie H, Zhang L, Tie L, Luo J, Mao X, Zhang B, Deng X, Zhang S, Qian M, Li S, Zhou X.   +20 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Drivers of innovation value: simulation for new drug pricing evaluation based on system dynamics modelling. [PDF]

Front Pharmacol
Xing Q, Cheng W, Wang W, Jin C, Wang H.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Correction: Ex-ante impact of pest des petits ruminant control on micro and macro socioeconomic indicators in Senegal: A system dynamics modelling approach. [PDF]

PLoS One
Aboah J, Apolloni A, Duboz R, Wieland B, Kotchofa P, Okoth E, Dione M.   +6 more
europepmc   +1 more source