Results 81 to 90 of about 20,853,741 (308)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Influence of SST‐Precipitation Relationship Over the Equatorial Western Pacific on Simulation of the Madden‐Julian Oscillation

Geophysical Research Letters
Capabilities of 43 models of the Coupled Model Intercomparison Project Phase 6 (CMIP6) to simulate the Madden‐Julian Oscillation (MJO) were compared in this study.
Guiwan Chen, Jian Ling, Ziniu Xiao, Chongyin Li, Chidong Zhang   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reducing childhood overweight and obesity : can the target be reached by 2025?

, 2017
The increasing prevalence of childhood overweight and obesity is raising significant concern about lasting health effects on individuals, as well as social and economic impacts.
Heffernan, Mark (R20258), McDonnell, Geoff, Atkinson, Jo-An, Li, Vincy, Prodan, Ante (R16550), Roberts, Nick, Davison, Jacqueline, Freebairn, Louise   +7 more
core  

Input and output data analysis for system dynamics modelling using the tidyverse libraries of R

, 2018
From a number of perspectives, system dynamics is a data‐intensive activity. First, each modelling challenge addresses behaviour over time, where historical time series data inform the model‐building process, and techniques such as calibration and ...
Duggan, Jim, Jim Duggan
core   +1 more source

The role of mountains in shaping the global meridional overturning circulation

Nature Communications
The meridional overturning circulation (MOC) in the ocean is a key player in the global climate system, while continental topography provides an essential backdrop to the system.
Haijun Yang, Rui Jiang, Qin Wen, Yimin Liu, Guoxiong Wu, Jianping Huang   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Concerted Run on the DSB Bank: An Exploratory System Dynamics Approach

, 2010
In this paper, an Exploratory System Dynamics model of a concerted run is first of all presented. The immediate cause for modelling a concerted bank run was the mediatised call for a run on the DSB bank.
Hamarat, C. (author), Pruyt, E. (author), Pruyt, E., Hamarat, C.   +3 more
core   +1 more source

Natural capital and ecosystem services for sustainable livelihoods in Costa Vicentina, Portugal

Frontiers in Marine Science, 2014
The OpenNESS project, funded by EC FP7, aims to translate the concepts of Natural Capital (NC) and Ecosystem Services (ES) into operational frameworks that provide tested, practical and tailored solutions for integrating ES into land, water and urban ...
Paula Antunes
doaj   +1 more source