Results 91 to 100 of about 20,853,741 (308)

Modelling Wholesale Company’s Supply Chain Using System Dynamics

Transport and Telecommunication, 2020
Research is based on wholesale and distribution operations of real-life case company, and in this setting, the most critical part of company’s supply chain is the inventory replenishment to warehouse (Distribution Center) as well as fulfilling and ...
Kiisler Ain, Hilmola Olli-Pekka
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Building Adaptive and Resilient Distance Military Education Systems Through Data-Driven Decision-Making

Systems
Distance learning has become essential to higher education, yet its application in military officer training presents unique academic, operational, and security challenges.
Svajone Bekesiene, Aidas Vasilis Vasiliauskas   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Influenza A(H1N1)v Pandemic: An Exploratory System Dynamics Approach

, 2010
This paper presents a small exploratory System Dynamics model related to the dynamics of the 2009 flu pandemic, also known as the Mexican flu, swine flu, or A(H1N1)v.
Hamarat, C. (author), Pruyt, E. (author), Pruyt, E., Hamarat, C.   +3 more
core   +1 more source

The Smart Home Services Diffusion Process: A System Dynamics Model [PDF]

, 2016
The application of smart technologies for domestic environment has been around for a while. But the market diffusion of such products and services has not seen yet a significant growth.
DE MARCO, Alberto, GHAJARGAR, MALIHEH, Eleonora, Fiore, ZENEZINI, GIOVANNI, Maliheh, Ghajargar, Giovanni, Zenezini, FIORE, ELEONORA, Alberto, De Marco   +7 more
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Dynamical systems modelling

, 2021
Chapter 26 focuses on dynamic systems modelling, a rigorous approach for studying how causal interactions within a social-ecological systems (SES) lead to dynamics at the system level. Dynamical systems modelling provides conceptual, mathematical and computational tools to deal with key SES concepts such as feedbacks, non-linearity and regime shifts ...
Steven J. Lade, John M. Anderies, Paul Currie, Juan C. Rocha   +3 more
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source