Results 91 to 100 of about 136,148 (315)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The Influenza A(H1N1)v Pandemic: An Exploratory System Dynamics Approach
, 2010 This paper presents a small exploratory System Dynamics model related to the dynamics of the 2009 flu pandemic, also known as the Mexican flu, swine flu, or A(H1N1)v.
Hamarat, C. (author) +3 more
core
Supporting policy analysis in the Dutch rail sector using System Dynamics
, 2013 With a sizeable expected growth of demand for rail transport in the Netherlands in the coming decades, and limited resources for expansion of the rail network, intensified utilization of the infrastructure is to be expected.
Mannaerts, A. (author) +7 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
On the design of hybrid simulation models, focussing on the agent-based system dynamics combination [PDF]
, 2014 ©Cranfield University, 2014There is a growing body of literature reporting the application of hybrid simulations to inform decision making. However, guidance for the design of such models, where the output depends upon more than one modelling paradigm ...
Swinerd, Chris
core
Numerical methods in vehicle system dynamics: state of the art and current developments
, 2011 Robust and efficient numerical methods are an essential prerequisite for the computer based dynamical analysis of engineering systems. In vehicle system dynamics, the methods and software tools from multibody system dynamics provide the integration ...
Arnold, Martin +5 more
core +1 more source
SystemsDistance learning has become essential to higher education, yet its application in military officer training presents unique academic, operational, and security challenges.
Svajone Bekesiene +1 more
doaj +1 more source
Simulation Modelling and Heuristics Optimization of Material Flow of the Port Cargo System
Promet (Zagreb), 2006 Simulation Modelling, together with System Dynamics andintensive use of modem digital computer, which means massiveapplication, today very inexpensive and at the same timevery powerful personal computers (PCs), is one of the mostsuitable and effective ...
Joško Dvornik +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Open Source System Dynamics with Simantics and OpenModelica
, 2011 We will introduce a new system dynamic modelling and simulation environment based on open source components. The development was initiated by a group of active system dynamics modellers who had needs and ideas for an open toolset.
Lempinen, Teemu +3 more
core