Results 101 to 110 of about 20,853,741 (308)
Design classes for hybrid simulations involving agent-based and system dynamics models [PDF]
, 2012 Hybrid simulation involves the use of multiple simulation paradigms, and is becoming an increasingly common approach to modelling modern, complex systems.
McNaught, Ken R., Swinerd, Chris
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
A system dynamics approach towards nearly zero energy districts
The transition to near-zero energy districts is shaped by a complex interplay of stakeholder interests, technological complementarities, and market dynamics.
Zapata Riveros, Juliana +1 more
core +2 more sources
The Fear Management Model: Building an Integrative Fear Appeal Theory through System Dynamics [PDF]
, 2016 This paper attempts to refine the Extended Parallel Process Model by adding the notion of hope to highlight the significant role of fear in fear appeals.
Han, Charles C.
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
System Dynamics based simulation and gaming: a case of transparent competing companies [PDF]
, 2000 SITMECOM 1.0 PC is a multifunctional simulator that represents three companies competing in real time in the same market. Each firm can be simulated on a different computer, which is linked to the others in one of the following ways: via a direct cable
Ruiz del Castillo, José Carlos +2 more
core +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Informatics in Medicine Unlocked, 2019 Background and objective: The understanding of complex biological systems performance is one of the key issues in physiology, and several computational methods based on computer simulation have been applied to determine the behaviour of nonlinear systems.
J. Fernandez de Canete +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source