Results 111 to 120 of about 136,148 (315)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Scarcity of Minerals and Metals: A Generic Exploratory System Dynamics Model

, 2010
Possible short, medium and/or long term scarcity of minerals/metals may actually pose a threat to modern societies. Its potentially disruptive societal consequences qualify this issue for exploration from a world/regional security point of view.
Pruyt, E. (author), Pruyt, E.
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Resilient by design: a modelling approach to support scenario and policy analysis in the Olifants River Basin, South Africa

, 2016
In this paper, we report on a concerted modelling effort in the South African water resources sector in which system dynamics provides the paradigmatic framing for both a stakeholder engagement process and for developing an underpinning, integrative ...
Pollard, S (author), Andres Diaz, Fabio (author), Biggs, H (author), Chihambakwe, Kundai (author), Slinger, J (author), Jonker, Willem (author), York, Theo (author), Clifford Holmes, J.K.V. (author)   +7 more
core  

The Delft Method for System Dynamics

The Delft Method for System Dynamics (SD) is a proven method for learning basic SD. The method focuses on learning by doing: first you try to work through an exercise, and if you do not understand something, then you can look up the theory.
Slinger, Jill, Steinmann, Patrick, Kubli, Merla, van der Heijde, Floris, Thissen, Wil, Pruyt, Erik, d'Hont, Floortje, Auping, Willem, van Daalen, Els   +8 more
core   +1 more source

Hybrid modelling case studies

, 2014
The objective of this chapter is to demonstrate the use of hybrid modelling for management decision support. The chapter presents three separate case studies that are unified both by the common theme of using different modelling techniques in a hybrid ...
Sadsad, Rosemarie, Sally Brailsford, Harper, Paul Robert, Geoff McDonnell, Joe Viana, Desai, Mitul. S., McDonnell, Geoff, Desai, Shivam, Rosemarie Sadsad, Viana, Joe, Shivam M. Desai, Brailsford, S.C., Brailsford, Sally, Harper, Paul, Paul Harper   +14 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Exploring carbon futures in the EU power sector: Using Exploratory System Dynamics Modelling and Analysis to explore policy regimes under deep uncertainty

, 2013
The European Emissions Trading Scheme (ETS) in combination with other renewable electricity (RES-E) support schemes such as (premium) feed-in tariffs or tradable green certificates do not guarantee a carbon neutral power sector in 2050.
Hamarat, C. (author), Loonen, E. (author), Pruyt, E. (author), Pruyt, E., Hamarat, C., Loonen, E.   +5 more
core  

Planning for healthcare services during the COVID-19 pandemic in the Southeast of England: a system dynamics modelling approach. [PDF]

BMJ Open, 2023
George A, Lacey P, Badrinath P, Gray A, Turner P, Harwood C, Gregson M.   +6 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source