, 2010 The main goal of this paper is to explain and illustrate different exploratory uses of small System Dynamics models for analysis and decision support in case of dynamically complex issues that are deeply uncertain.
Pruyt, E. (author) +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Analysing the uncertain future of copper with three exploratory system dynamics models
, 2012 High copper prices, the prospect of a transition to a more sustainable energy mix and increasing copper demands from emerging economies have not led to an in-creased attention to the base metal copper in mineral scarcity discussions. The copper system is
Kwakkel, J.H. (author) +5 more
core
Trends in adults' energy imbalance gaps over two decades in Belgium using system dynamics modelling. [PDF]
BMC Nutr, 2023 Fallah-Fini S +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Which is more appropriate: a multi-perspective comparison between systems dynamics and discrete event simulation [PDF]
, 2008 System Dynamics (SD) and Discrete Event Simulation (DES) are two established simulation tech-niques for simulating the dynamics of a system. Both have been widely used in modelling business de-cisions.
Eldabi, T
core
System dynamics modelling to engage community stakeholders in addressing water and sugar sweetened beverage consumption. [PDF]
Int J Behav Nutr Phys Act, 2022 Brown AD +7 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Ex-ante impact of pest des petits ruminant control on micro and macro socioeconomic indicators in Senegal: A system dynamics modelling approach. [PDF]
PLoS One, 2023 Aboah J +6 more
europepmc +1 more source
Methods for Project Tracking in Creative Environment
Acta Informatica Pragensia, 2017 The objective of this paper is to design new alternative methods for project tracking in creative industry environment. One of the research method is system dynamics modelling.
Eva Šviráková
doaj +1 more source