Results 141 to 150 of about 136,148 (315)

A comparison of discrete event simulation and system dynamics for modelling health care systems

, 2001
In this paper we discuss two different approaches to simulation, discrete event simulation and system dynamics. Both have been used widely in the health care domain, although there are fewer applications of system dynamics.
Sally Brailsford, Hilton, N.A., Brailsford, S.C., Nicola Hilton   +3 more
core  

System dynamics modelling of health workforce planning to address future challenges of Thailand's Universal Health Coverage. [PDF]

Hum Resour Health, 2021
Leerapan B, Teekasap P, Urwannachotima N, Jaichuen W, Chiangchaisakulthai K, Udomaksorn K, Meeyai A, Noree T, Sawaengdee K.   +8 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Correction to: System dynamics modelling of health workforce planning to address future challenges of Thailand's Universal Health Coverage. [PDF]

Hum Resour Health, 2021
Leerapan B, Teekasap P, Urwannachotima N, Jaichuen W, Chiangchaisakulthai K, Udomaksorn K, Meeyai A, Noree T, Sawaengdee K.   +8 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Systems modelling of new media services [PDF]

, 2011
Energy consumption has long been identified as a major sustainability issue through its contribution to global greenhouse gas emissions and the limited supply of non-renewable resources.
Shabajee, P, Preist, CW, Yearworth, M, Schien, D   +3 more
core  

Using system dynamics modelling to estimate the costs of relaxing health system constraints: a case study of tuberculosis prevention and control interventions in South Africa. [PDF]

Health Policy Plan, 2022
Bozzani FM, Diaconu K, Gomez GB, Karat AS, Kielmann K, Grant AD, Vassall A.   +6 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Formal Behaviour Classification under Uncertainty: Applying Formal Analysis to System Dynamics

, 2014
A study was performed by the author on formal analysis of uncertain non-linear systems in the context of System Dynamics (SD). The objective of this study was to develop a more insightful method to classify model behaviour for exploratory modelling.
Kuipers, J., Kuipers, J. (author)
core  

Policy innovation and emergence of innovative health technology: The system dynamics modelling of early COVID-19 handling in Indonesia. [PDF]

Technol Soc, 2021
Aminullah E, Erman E.
europepmc   +1 more source