Results 151 to 160 of about 20,853,741 (308)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

The Structure and Dynamics of the Residential Building Environment: What Mechanisms Determine the Development of the Building Stock? [PDF]

, 2007
Grösser, Stefan N., Ulli-Beer, Silvia
core  

Using Small Models for Big Issues: Exploratory System Dynamics Modelling and Analysis for Insightful Crisis Management

, 2010
The main goal of this paper is to explain and illustrate different exploratory uses of small System Dynamics models for analysis and decision support in case of dynamically complex issues that are deeply uncertain.
Pruyt, E. (author), Pruyt, E., Erik Pruyt   +2 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Exploring carbon futures in the EU power sector: Using Exploratory System Dynamics Modelling and Analysis to explore policy regimes under deep uncertainty

, 2013
The European Emissions Trading Scheme (ETS) in combination with other renewable electricity (RES-E) support schemes such as (premium) feed-in tariffs or tradable green certificates do not guarantee a carbon neutral power sector in 2050.
Hamarat, C. (author), Loonen, E. (author), Pruyt, E. (author), Pruyt, E., Hamarat, C., Loonen, E.   +5 more
core   +1 more source

The Delft Method for System Dynamics

The Delft Method for System Dynamics (SD) is a proven method for learning basic SD. The method focuses on learning by doing: first you try to work through an exercise, and if you do not understand something, then you can look up the theory.
Slinger, Jill, Steinmann, Patrick, Kubli, Merla, van der Heijde, Floris, Thissen, Wil, Pruyt, Erik, d'Hont, Floortje, Auping, Willem, van Daalen, Els   +8 more
core   +1 more source

Cybersecurity dynamics in software development environment. What system traps do exist?

, 2020
Increasing dependency on information technology and an increasing number of cyber-attacks give rise to concerns about secure software development methods.
von Kutzschenbach, Michael, Zeijlemaker, Sander   +1 more
core  

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source