Results 131 to 140 of about 136,148 (315)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The low carbon transition in the UK building sector must make financial sense: a hybrid system dynamics bottom up modelling framework [PDF]

, 2018
The building sector contributes significantly to global energy consumption and CO2 emissions. It is urgent to reduce them through the retrofit of existing buildings and improved new building designs.
Papachristos, George
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A knowledge intervention to explore stakeholders’ understanding of a dynamic coastal nature reserve

, 2014
As quantitative modelling can be used to build stakeholder understanding for management decisions, and can help build consensus (Stave, 2003), a system dynamics modelling study of the abiotic dynamics of an archetypical small estuary, the Slufter in the ...
Goessen, P. (author), Slinger, J (author), d’Hont, Floortje (author), Slinger, J.H. (author), d’Hont, Floortje, D'Hont, F. (author), Goessen, Petra, Slinger, J.H., Goessen, P., Slinger, J, D'Hont, F., Goessen, Petra (author)   +11 more
core  

Using system dynamics modelling to assess the economic efficiency of innovations in the public sector - a systematic review. [PDF]

PLoS One, 2022
Jadeja N, Zhu NJ, Lebcir RM, Sassi F, Holmes A, Ahmad R.   +5 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Lumped-Parameter Modelling of Cardiovascular System Dynamics under Different Healthy and Diseased Conditions [PDF]

, 2013
Cardiovascular disease is the most common cause of death in the modern society, and research into the diagnosis and treatment of cardiovascular diseases is an urgent task.
Shi, Yubing
core  

Optimizing Strategies for Improving Mental Health in Victoria, Australia during the COVID-19 Era: A System Dynamics Modelling Study. [PDF]

Int J Environ Res Public Health, 2022
Vacher C, Ho N, Skinner A, Robinson J, Freebairn L, Lee GY, Iorfino F, Prodan A, Song YJC, Occhipinti JA, Hickie IB.   +10 more
europepmc   +1 more source

Forecasting Infrastructure Needs, Environmental Impacts, and Dynamic Pricing for Electric Vehicle Charging

World Electric Vehicle Journal
In recent years, carbon dioxide (CO2) emissions have increased at the fastest rates ever recorded. This is a trend that contradicts global efforts to stabilise greenhouse gas (GHG) concentrations and prevent long-term climate change.
Osama Jabr, Ferheen Ayaz, Maziar Nekovee, Nagham Saeed   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source