Results 91 to 100 of about 18,012,949 (286)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Maintenance of Rainwater Harvesting (RWH) system in Malaysia / Hafsah Yahaya [PDF]

, 2012
The application of Rainwater harvesting (RWH) system in Malaysia is still considered as a new phenomenon. However, with the support and effort of government in promoting the application of RWH in building, the number of building using the RWH is ...
Hafsah, Yahaya
core  

RAPO: An Automated Performance Optimization Tool for Redis Clusters in Distributed Storage Metadata Management

IEEE Access
Distributed storage systems are well-equipped to address the demands of massive data storage and rapid access in the era of big data. However, as the scale of these systems continues to expand, challenges related to data localization, performance ...
Yunkai Zhu, Tian Xia, Te Zhu, Zhoujie Zhao, Kexin Li, Xingbo Hu   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Techno-Economic Assessment of Battery Energy Storage Technologies and Energy Management Strategies for Hydrogen Hosting Capacity in Microgrids

IEEE Access
This paper presents a techno-economic evaluation of battery energy storage systems (BESSs) integrated into hydrogen-based microgrids (MGs). Eight BESS technologies are investigated to quantify their impact on the hydrogen energy storage hosting capacity (
Mohamed M. Refaat, Mujahed Al-Dhaifallah, Abd El-Fattah A. Omran   +2 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

OPTIMIZER SYSTEM AND METHOD

The present disclosure provides a system and method for managing the payment of invoices using an optimizer system. The method comprises receiving, by an optimizer system, an accounts receivable file comprising a plurality of invoices from an accounts ...
Sarkar, Sayantika, Li, John H., Choi, Raymond B., Krikorian, Shari   +3 more
core   +1 more source

Linking component importance to optimisation of preventive maintenance policy [PDF]

, 2016
In reliability engineering, time on performing preventive maintenance (PM) on a component in a system may affect system availability if system operation needs stopping for PM.
Chen, Yi, Wang, Zhonglai, Wu, Shaomin, Wu, Qingtai   +3 more
core   +1 more source

Optimization of multi-chamber mufflers with reverse-flow ducts by algorithm of simulated annealing

Archives of Acoustics, 2013
Shape optimization on mufflers within a limited space volume is essential for industry, where the equipment layout is occasionally tight and the available space for a muffler is limited for maintenance and operation purposes.
Ying-Chun CHANG, Min-Chie CHIU
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source