Results 81 to 90 of about 18,012,949 (286)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Planned maintenance systems with respect to modern manufacturing strategies [PDF]

, 1989
To remain competitive in todays's increasingly automated environment, manufacturing industry must take a more proactive and strategic attitude towards maintenance. This thesis applies these concepts, as a case study?
Quinn, Brigid Mary
core  

GrCRA PCRTAM net based hybrid approach for intelligent control and optimal power management in renewable integrated power distribution systems

Scientific Reports
Power management in advanced power distribution systems integrated with Photovoltaic (PV) sources, batteries, and Super Capacitors (SCs) plays a vital role in ensuring stable and efficient energy flow.
S. Arulkumar, Mohammad Arif, Pramoda Patro, M. Siva Ramkumar, M. Sivaramkrishnan, Arunkumar Munimathan, Javed Khan Bhutto, Hadi Hakami, Amanuel Zewdie   +8 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A Comprehensive Framework for Intelligent, Scalable, and Performance-Optimized Software Development

IEEE Access
Integrating Artificial Intelligence (AI) into the Software Development Life Cycle (SDLC) has become necessary to enhance efficiency, scalability, and performance in modern software systems.
Noor Arshad, Talal Ashraf Butt, Muhammad Iqbal   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Integrating the maintenance process: a framework to bridge design for maintenance to prescriptive maintenance [PDF]

, 2022
Due to the rising concern over the impact of global warming and significant climate changes, the aviation industry is looking for solutions to reduce emissions.
Martinetti, Alberto, Jain, Ashrith, Giacotto, Alessandro, Costa Marques, Henrique   +3 more
core   +1 more source

MULTI-AGENT SYSTEM FOR AUTOMATIC PLANNING AND MANAGEMENT OF ENGINEERING CHANGES AT A RADIOELECTRONICS ENTERPRISE

Надежность и качество сложных систем
Background. Modern radio-electronic enterprises have to maintain consumer interest by continuously improving their products, developing new modifications and introducing engineering changes into the design and manufacturing technology.
G.Kh. Irzaev, A.A. Adamova, N.K. Yurkov
doaj   +1 more source

Online Fault Detection, Classification and Localization in PV Arrays Using Feedforward Neural Networks and Residual-Based Modeling

Technologies
Fast and reliable fault detection is critical in photovoltaic (PV) systems to improve reliability and energy yield and reduce maintenance costs, ensuring safe and efficient operation under varying operating conditions.
Kareem Adel Mohamed, Nahla E. Zakzouk, Mostafa Abdelgeliel, Karim H. Youssef   +3 more
doaj   +1 more source