Results 61 to 70 of about 5,451 (253)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Online Fault Detection, Classification and Localization in PV Arrays Using Feedforward Neural Networks and Residual-Based Modeling

Technologies
Fast and reliable fault detection is critical in photovoltaic (PV) systems to improve reliability and energy yield and reduce maintenance costs, ensuring safe and efficient operation under varying operating conditions.
Kareem Adel Mohamed, Nahla E. Zakzouk, Mostafa Abdelgeliel, Karim H. Youssef   +3 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

MULTI-AGENT SYSTEM FOR AUTOMATIC PLANNING AND MANAGEMENT OF ENGINEERING CHANGES AT A RADIOELECTRONICS ENTERPRISE

Надежность и качество сложных систем
Background. Modern radio-electronic enterprises have to maintain consumer interest by continuously improving their products, developing new modifications and introducing engineering changes into the design and manufacturing technology.
G.Kh. Irzaev, A.A. Adamova, N.K. Yurkov
doaj   +1 more source

Techno-Economic Assessment of Battery Energy Storage Technologies and Energy Management Strategies for Hydrogen Hosting Capacity in Microgrids

IEEE Access
This paper presents a techno-economic evaluation of battery energy storage systems (BESSs) integrated into hydrogen-based microgrids (MGs). Eight BESS technologies are investigated to quantify their impact on the hydrogen energy storage hosting capacity (
Mohamed M. Refaat, Mujahed Al-Dhaifallah, Abd El-Fattah A. Omran   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

RAPO: An Automated Performance Optimization Tool for Redis Clusters in Distributed Storage Metadata Management

IEEE Access
Distributed storage systems are well-equipped to address the demands of massive data storage and rapid access in the era of big data. However, as the scale of these systems continues to expand, challenges related to data localization, performance ...
Yunkai Zhu, Tian Xia, Te Zhu, Zhoujie Zhao, Kexin Li, Xingbo Hu   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Optimization of multi-chamber mufflers with reverse-flow ducts by algorithm of simulated annealing

Archives of Acoustics, 2013
Shape optimization on mufflers within a limited space volume is essential for industry, where the equipment layout is occasionally tight and the available space for a muffler is limited for maintenance and operation purposes.
Ying-Chun CHANG, Min-Chie CHIU
doaj