Results 51 to 60 of about 5,451 (253)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Multi-objective Approach for Dynamic Economic Emission Dispatch Problem Considering Power System Reliability and Transmission Loss Prediction Using Cascaded Forward Neural Network

International Journal of Computational Intelligence Systems
This study addresses the significant problem of Dynamic Economic Emission Dispatch (DEED), a critical consideration in power systems from both economic and environmental protection viewpoints.
Nalini Nagulsamy, Kumar Chandrasekaran, Premkumar Manoharan, Bizuwork Derebew   +3 more
doaj   +1 more source

A Health Management Technology Based on PHM for Diagnosis, Prediction of Machine Tool Servo System Failures

Applied Sciences
The computer numerically controlled (CNC) system is the key functional component of CNC machine tool control systems, and the servo drive system is an important part of CNC systems.
Qiang Cheng, Yong Cao, Zhifeng Liu, Lingli Cui, Tao Zhang, Lei Xu   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Intelligent Pattern Recognition Using Equilibrium Optimizer With Deep Learning Model for Android Malware Detection

IEEE Access
Android malware recognition is the procedure of mitigating and identifying malicious software (malware) planned to target Android operating systems (OS) that are extremely utilized in smartphones and tablets.
Mohammed Maray, Mashael Maashi, Haya Mesfer Alshahrani, Sumayh S. Aljameel, Sitelbanat Abdelbagi, Ahmed S. Salama   +5 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

GrCRA PCRTAM net based hybrid approach for intelligent control and optimal power management in renewable integrated power distribution systems

Scientific Reports
Power management in advanced power distribution systems integrated with Photovoltaic (PV) sources, batteries, and Super Capacitors (SCs) plays a vital role in ensuring stable and efficient energy flow.
S. Arulkumar, Mohammad Arif, Pramoda Patro, M. Siva Ramkumar, M. Sivaramkrishnan, Arunkumar Munimathan, Javed Khan Bhutto, Hadi Hakami, Amanuel Zewdie   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Comprehensive Framework for Intelligent, Scalable, and Performance-Optimized Software Development

IEEE Access
Integrating Artificial Intelligence (AI) into the Software Development Life Cycle (SDLC) has become necessary to enhance efficiency, scalability, and performance in modern software systems.
Noor Arshad, Talal Ashraf Butt, Muhammad Iqbal   +2 more
doaj   +1 more source