Results 71 to 80 of about 18,012,949 (286)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Optimizer Algorithms for Supervisory Control : Enabling Supervisor Input:(SUPEROPT D2) [PDF]

, 2012
This document reports the methods developed by the SUPEROPT project for supervisor interaction with optimizers. Two mathematical forms for an optimizer to support a Multi-Sector Controller are presented and compared, including various constraint forms to
Richards, Arthur G, Turnbull, Oliver D N
core  

Multi-objective Approach for Dynamic Economic Emission Dispatch Problem Considering Power System Reliability and Transmission Loss Prediction Using Cascaded Forward Neural Network

International Journal of Computational Intelligence Systems
This study addresses the significant problem of Dynamic Economic Emission Dispatch (DEED), a critical consideration in power systems from both economic and environmental protection viewpoints.
Nalini Nagulsamy, Kumar Chandrasekaran, Premkumar Manoharan, Bizuwork Derebew   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Knowledge Management for Maintenance, Repair and Service of Manufacturing System [PDF]

, 2014
Manufacturing equipment, such as numerical controlled machines and assembly cranes, requires constant maintenance and service in their operating lifecycle.
Wan, S., Li, D., Evans, R.D., Gao, J.X.
core  

A Health Management Technology Based on PHM for Diagnosis, Prediction of Machine Tool Servo System Failures

Applied Sciences
The computer numerically controlled (CNC) system is the key functional component of CNC machine tool control systems, and the servo drive system is an important part of CNC systems.
Qiang Cheng, Yong Cao, Zhifeng Liu, Lingli Cui, Tao Zhang, Lei Xu   +5 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Intelligent Pattern Recognition Using Equilibrium Optimizer With Deep Learning Model for Android Malware Detection

IEEE Access
Android malware recognition is the procedure of mitigating and identifying malicious software (malware) planned to target Android operating systems (OS) that are extremely utilized in smartphones and tablets.
Mohammed Maray, Mashael Maashi, Haya Mesfer Alshahrani, Sumayh S. Aljameel, Sitelbanat Abdelbagi, Ahmed S. Salama   +5 more
doaj   +1 more source