Results 151 to 160 of about 2,272,897 (309)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Selected 'Starter kit' energy system modelling data for selected countries in Africa, East Asia, and South America (#CCG, 2021). [PDF]

Data Brief, 2022
Allington L, Cannone C, Pappis I, Cervantes Barron K, Usher W, Pye S, Brown E, Howells M, Zachau Walker M, Ahsan A, Charbonnier F, Halloran C, Hirmer S, Cronin J, Taliotis C, Sundin C, Sridharan V, Ramos E, Brinkerink M, Deane P, Gritsevskyi A, Moura G, Rouget A, Wogan D, Barcelona E, Niet T, Rogner H, Bock F, Quirós-Tortós J, Angulo-Paniagua J, Krishnamurthy S, Harrison J, To LS.   +32 more
europepmc   +1 more source

Dynamic Modelling System of Indonesia's Crude Palm Oil Sustainable Supply Chain Management [PDF]

, 2018
The agricultural sector has an important role in economic activity in Indonesia. It is reflected from its contribution to the Gross Domestic Product (GDP) of approximately 13.46 percent in 2016 and its ability to absorb 31.86 percent of Indonesian ...
Cahyadi, E. R. (Eko), Munandar, J. M. (Jono), Muzayanah, F. N. (Fety)   +2 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Using the max-p regions problem algorithm to define regions for energy system modelling. [PDF]

MethodsX, 2021
Fleischer CE.
europepmc   +1 more source

Validation of Finite Element Modelling of Multielectrode Capacitive System for Process Tomography Flow Imaging [PDF]

, 1993
Finite element modelling of process tomography sensor systems is necessary for their CAD both for performance evaluation and design optimization. This paper involves the validation of finite element models of a 12-electrode capacitive sensor system for ...
Abdullah, F., Khan, S.
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mathematical modelling of the cardiovascular system

, 2002
In this paper we will address the problem of developing mathematical models for the numerical simulation of the human circulatory system.
Quarteroni, Alfio
core