Results 141 to 150 of about 18,821,561 (297)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Minimax System Modelling and Design [PDF]
, 1973 Computer-aided system modelling and design for minimax objectives have been considered in detail. A new algorithm for minimax approximation, called the grazor search method, has been proposed and successfully used on a number of network design ...
Srinivasan, Thandangorai
core
Design scoping and systems modelling of ST-E1 using the PyTok power plant simulation code
Nuclear FusionTo support the pre-concept design of Tokamak Energy’s (TEs) ST-E1 fusion power plant, we developed a new systems code, PyTok. PyTok codifies plasma physics and engineering constraints within a pure Python, object-oriented framework designed for rapid ...
C.L. Wilson +8 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2015 The occurrence of extreme events can challenge the capacity of water utilities to deliver potable water of sufficient quality with respect to minimising health risks to consumers. As a consequence, proactive risk-assessment and decision support tools are
Roiko, A +3 more
core
Evaluation of System Modelling Techniques for Waste Identification in Lean Healthcare Applications. [PDF]
Risk Manag Healthc Policy, 2020 Alkaabi M +8 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Tools and analytic techniques to synthesise community knowledge in CBPR using computer-mediated participatory system modelling. [PDF]
NPJ Digit Med, 2020 Hayward J +4 more
europepmc +1 more source