Results 31 to 40 of about 38,629 (251)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Comparison of the Combined Shielding Effectiveness Based on Experimental Studies of Overhead Power Lines Magnetic Field 3D Model [PDF]

Problems of the Regional Energetics
The aim of the work is an experimental study of the efficiency of combined shielding of the magnetic field generated by transmission lines (HVPL) with single-circuit and triangular arrangements of wires and double-circuit transmission lines with a ...
Bovdui I.V.
doaj   +1 more source

The influence of common component on myoelectric pattern recognition

Journal of International Medical Research, 2020
Objective Using the Twente Medical Systems international B.V. (TMSi) electromyography (EMG) system, active signal shielding was applied to clean signals and create data without interference and cable movement artifacts. TMSi, used in high-density surface
Bo Yao, Yun Peng, Xu Zhang, Yingchun Zhang, Ping Zhou, Jiangbo Pu   +5 more
doaj   +1 more source

Optimization of spatial arrangement of magnetic field sensors of closed loop system of overhead power lines magnetic field active silencing

Electrical engineering & Electromechanics, 2023
Aim. Development of a method for optimization of spatial arrangement and angular position of magnetic field sensors of a closed system to ensure maximum efficiency of active silencing canceling of the magnetic field generated by overhead power lines ...
B. I. Kuznetsov, T. B. Nikitina, I. V. Bovdui, O. V. Voloshko, V. V. Kolomiets, B. B. Kobylianskyi   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Method for design of two-level system of active shielding of power frequency magnetic field based on a quasi-static model

Electrical engineering & Electromechanics
Aim. Development of method for design a two-level active shielding system for an industrial frequency magnetic field based on a quasi-static model of a magnetic field generated by power line wires and compensating windings of an active shielding system ...
B. I. Kuznetsov, A. S. Kutsenko, T. B. Nikitina, I. V. Bovdui, V. V. Kolomiets, B. B. Kobylianskyi   +5 more
doaj   +1 more source

On-scalp MEG system utilizing an actively shielded array of optically-pumped magnetometers

NeuroImage, 2018
Abstract The spatial resolution of magnetoencephalography (MEG) can be increased from that of conventional SQUID-based systems by employing on-scalp sensor arrays of e.g. optically-pumped magnetometers (OPMs). However, OPMs reach sufficient sensitivity for neuromagnetic measurements only when operated in a very low absolute magnetic ...
Zetter, Rasmus, Grön, Mikael, Hakkarainen, Karoliina, Parkkonen, Lauri, Iivanainen, Joonas   +5 more
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Reducing the Magnetic Field Level of Single-Circuit Overhead Power Lines in Multi-Storey Buildings by Means of Active and Passive Shielding [PDF]

Problems of the Regional Energetics
The purpose of the work is a theoretical and experimental study of the effectiveness of combined shielding, including active and passive shielding using a continuous screen, of the magnetic field generated by single-circuit power lines with a triangular ...
Kuznetsov B.I., Kutsenko A.S., Nikitina T.B., Bovdui I.V., Chunikhin K.V., Voloshko O.V.   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source