Results 61 to 70 of about 279,696 (263)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Stability Analysis of a System of Exponential Difference Equations

Discrete Dynamics in Nature and Society, 2014
We study the boundedness character and persistence, existence and uniqueness of positive equilibrium, local and global behavior, and rate of convergence of positive solutions of the following system of exponential difference equations: xn+1=(α1+β1e-xn ...
Q. Din, K. A. Khan, A. Nosheen
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

CALCULATION OF THERMODYNAMIC CHARACTERISTICSOF THE ASCENDING SWIRLING FLOW WITH FIVE SOURCES OF HEATING

Известия высших учебных заведений: Нефть и газ, 2017
Calculations of the thermodynamic characteristics of air flows were carried out when several local sources were heated by the underlying surface. The basic mathematical model is the complete system of Navier-Stokes equations with constant coefficients of
D. D. Barannikova, A. G. Obukhov
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

On the solutions of a three-dimensional system of difference equations

Kuwait Journal of Science, 2015
In this paper, we obtain the explicit solutions of the three-dimensional system of difference equations with multiplicative terms, which extended some results in literature.
Yasin Yazlık, Durhasan Turgut Tollu, Necati Taşkara   +2 more
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Behavior of a Competitive System of Second-Order Difference Equations

The Scientific World Journal, 2014
We study the boundedness and persistence, existence, and uniqueness of positive equilibrium, local and global behavior of positive equilibrium point, and rate of convergence of positive solutions of the following system of rational difference equations ...
Q. Din, T. F. Ibrahim, K. A. Khan
doaj   +1 more source

Product-type system of difference equations of second-order solvable in closed form

Electronic Journal of Qualitative Theory of Differential Equations, 2015
This paper presents solutions of the following second-order system of difference equations $$x_{n+1}=\frac{y_n^a}{z_{n-1}^b},\qquad y_{n+1}=\frac{z_n^c}{x_{n-1}^d},\qquad z_{n+1}=\frac{x_n^f}{y_{n-1}^g},\qquad n\in N_0,$$ where $a,b,c,d,f,g\in Z$, and ...
Stevo Stevic
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source