Results 71 to 80 of about 175,966,960 (244)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

On a k-Order System of Lyness-Type Difference Equations

Advances in Difference Equations, 2007
We consider the following system of Lyness-type difference equations: x1(n+1)=(akxk(n)+bk)/xk−1(n−1), x2(n+1)=(a1x1(n)+b1)/xk(n−1), xi(n+1)=(ai−1xi−1(n)+bi−1)/xi−2(n−1), i=3,4,…,k, where ai, bi, i=1,2,…,k,
G. Papaschinopoulos, C. J. Schinas, G. Stefanidou   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Asymptotic Behavior of Certain Non-Autonomous Planar Competitive Systems of Difference Equations

, 2023
This paper investigates the dynamics of non-autonomous competitive systems of difference equations with asymptotically constant coefficients. We are mainly interested in global attractivity results for such systems and the application of such results to ...
Susan Trolle, Mustafa R. S. Kulenović, Zehra Nurkanović, Mehmed Nurkanović   +3 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Solvability of a close to symmetric system of difference equations

Electronic Journal of Differential Equations, 2016
The problem of solvability of a close to symmetric product-type system of difference equations of second order is investigated. Some recent results in the literature are extended.
Stevo Stevic, Bratislav Iricanin, Zdenek Smarda   +2 more
doaj  

Exact Solutions of System of Fourth-Order Difference Equations

Pan-American Journal of Mathematics
In this paper, we derive the solutions of system difference equations xn+1 = xn−1yn−3 / yn−1(a + bxn−1yn−3), yn+1 = yn−1xn−3 / xn−1(c + dyn−1xn−3), n∈N0, where the parameters a, b, c, d are real numbers and the initial conditions x−i and y−i for (i = 0,
Messaoud Berkal, Raafat Abo-Zeid
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

On the system of rational difference equations x(n) = A+(1)over-bar y(n-p), y(n) = A+(gamma(n-1))over-bar x(n-r)y(n-5) [PDF]

, 2006
In this paper, we study the behavior of the positive solutions of the system of two difference equations [GRAPHICS] where p >= 1, r >= 1, s >= 1, A >= 0, and x(1-r), x(2-r),..., x(0), y(1-max) {p.s},..., y(0) are positive real numbers.
Yang, X., Megson, G.M., Evans, D.J., Zhang, Y., Yang, X.F., Hongjian Xi, Taixiang Sun   +6 more
core   +1 more source