Results 71 to 80 of about 279,696 (263)

Solutions Of The System Of Maximum Difference Equations

MANAS: Journal of Engineering, 2014
The behaviour of the solutions of the following system of difference equations is examined.
Dağıstan Şimşek, Ahmet Doğan
doaj  

On a multidimensional close-to-cyclic system of difference equations

Miskolc Mathematical Notes
This paper investigates the solvability and dynamic properties of the following multidimensional close-to-cyclic system of nonlinear difference equations yn+1 (i)=aiyn (i+1) (y n−k (i+1))pi+1+b i (yn−k+1 (i))pi;n∈ℕ0,yn (i+k)=yn (i),pi+k=pi,ai+k=ai,bi+
Yacine Halim, Asma Allam, Ibraheem M. Alsulami   +2 more
doaj   +1 more source

On a system of difference equations of third order solved in closed form

Journal of Innovative Applied Mathematics and Computational Sciences, 2021
In this work, we show that the system of difference equations xn+1=(ayn-2xn-1yn+bxn-1yn-2+cyn-2+d)/(yn-2xn-1yn), yn+1=(axn-2yn-1xn+byn-1xn-2+cxn-2+d)/(xn-2yn-1xn), where n belongs to the set of positive integer numbers, x-2, x-1, x0, y-2, y-1 and y0 are ...
Youssouf AKROUR, Nouressadat Touafek, Yacine Halim   +2 more
doaj  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Solutions of the System of Maximum Difference Equations

MANAS: Journal of Engineering, 2016
The behaviour and periodicity of the solutions of the following system of difference equations is ...
D. Şimşek, M. Eröz, B. Öğul
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

On a System of Two High-Order Nonlinear Difference Equations

Advances in Mathematical Physics, 2014
This paper is concerned with dynamics of the solution to the system of two high-order nonlinear difference equations xn+1=xn-k/(q+∏i=0kyn-i), yn+1=yn-k/(p+∏i=0kxn-i), k∈N+, n=0,1,…, where p,q∈(0,∞), x-i∈(0,∞), y-i∈(0,∞) and i=0,1,…,k.
Qianhong Zhang, Wenzhuan Zhang
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source