Results 121 to 130 of about 12,410 (294)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ANALISIS USABILITY PADA WEBSITE NAVIDOK MENGGUNAKAN METODE USABILITY TESTING DAN SYSTEM USABILITY SCALE (SUS) [PDF]

Pada era perkembangan teknologi saat ini semakin pesat dan memberikan dampak yang besar di berbagai bidang, salah satunya penggunaan website yang menjadi bagian penting dalam hal penyedia informasi.
Datu, Angela Liling
core  

Evaluasi Usability Aplikasi Pln Mobile Menggunakan Metode System Usability Scale

, 2023
PLN MOBILE adalah aplikasi mobile customer self service berbasis mobile yang terintegrasi dengan Aplikasi Pengaduan dan Keluhan Terpadu (APKT) dan Aplikasi Pelayanan Pelanggan Terpusat (AP2T).
Winoto Chandra, risky
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

USABILITY TESTING ANALYSIS ON PROFESSIONAL SOCIAL MEDIA USING THE SYSTEM USABILITY SCALE (SUS) METHOD

Usability is a critical aspect of digital product design, which determines how effective, efficient, and satisfying a product is for its users. This research aims to evaluate the level of usability of digital applications in a professional context using ...
fatikah aulia farhah, Fenny Purwani
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Evaluation of the Validity and Usability of the Mobile Application for Early Detection of Metabolic Syndrome: A Cross-Sectional Study

Jurnal Berita Ilmu Keperawatan
Metabolic syndrome is a cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus in adults. The development of a health application-based instrument is important.
Okti Sri Purwanti, Diaz Aziz Pramudita, Agus Sudaryanto, Tanjung Anita Sari Indah Kusmaningrum, Syarif Fathurozaq Wibowo, Ulfa Munawaroh Diniyah, Muhammad Hananfajri Rasyid, Danar Wasis Pambudi, Annisa Niken Larasati, Nimas Zuhrufana   +9 more
doaj   +1 more source

Evaluasi Usability Aplikasi Tiket.com Menggunakan Metode System Usability Scale (SUS)

CSRID (Computer Science Research and Its Development Journal)
Studi ini berfokus pada evaluasi kegunaan platform pemesanan tiket online, Tiket.com, yang meskipun populer, telah menerima banyak ulasan negatif dari pengguna. Tujuan utama dari penelitian ini adalah untuk menilai kegunaan platform tersebut guna mengidentifikasi area perbaikan yang dapat meningkatkan pengalaman pengguna.
Via Alfilaeni, Dwi Krisbiantoro, Gustin Setyaningsih   +2 more
openaire   +1 more source