Results 171 to 180 of about 42,961 (301)

Supporting IFRS 17 Readiness Through User-Centered Design and Usability Evaluation in Indonesian Insurance Information Systems

Sriwijaya International Journal of Dynamic Economics and Business
To comply with stringent IFRS 17 implementation standards in the insurance industry, Tugu Insurance has critically utilized the Tugu Insurance Core System (TICS) since January 2024 to enhance data collection process and data accuracy.
Asyhari Ichsan
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Usability Evaluation of a Central Monitoring System with AI-Based Cardiac Arrest Prediction in the ICU. [PDF]

J Clin Med
Oh J, Kim Y, Jang W.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Telerehabilitation Following Stroke: Development of Training Content and Evaluation of an App-Based Training Program. [PDF]

JMIR Rehabil Assist Technol
Ziller C, Gäumann S, Lüscher S, Paulissen N, Behrendt F, Suica Z, Crüts B, Gamerschlag L, Parmar K, Gerth HU, Bonati LH, Schuster-Amft C.   +11 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Usability and feasibility of INFORMA platform for computerized cognitive stimulation in mild cognitive impairment and early dementia: an 8-week multicenter study. [PDF]

Aging Clin Exp Res
Basso C, Zanella A, Simoni M, Fantozzi C, Gollin D, Ruaro C, Tiozzo Netti S, Zapparoli A, Padoan R, Gallucci M, Gallo L, Valentinis L, Ceci M, Dal Santo P, Ceccon A, Pradelli S, Marcon M, De Togni L, Musso AM, Riolo A, Gagni G, Gabelli C, Spano P, Therapists Informa Group (TIG).   +23 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Bringing AI to the OR: integrating a machine learning predictive model in the EHR - a pilot on user-friendliness. [PDF]

BMJ Health Care Inform
Ben Hmido S, Ingwersen E, Abder Rahim H, van Maanen M, Groot S, Schakel M, Rausch A, Kazemier G, Daams F.   +8 more
europepmc   +1 more source