Results 231 to 240 of about 3,721,345 (286)

Cushing's disease and negative MRI: a single-center series, systematic literature review, and meta-analysis. [PDF]

Neurosurg Rev
Ghidoni F, Madoglio A, Chiloiro S, di Bergamo LT, Vezzoli M, Serioli S, Cosentino G, Saraceno G, Lupi I, Urbani C, Licini M, Candrina R, Giampietro A, Pirola I, Cappelli C, Mattavelli D, Rampinelli V, Ferrari M, Bogazzi F, Cosottini M, Gasparotti R, Manetti L, Bianchi A, Nicolai P, Piazza C, Fontanella MM, Poliani PL, Doglietto F.   +27 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Systematic literature review of economic studies on nature-based social prescribing for health improvement. [PDF]

BMC Prim Care
Puntscher S, Stojkov I, Arvandi M, Kühne F, Conrads-Frank A, Papon V, Schmid D, Jahn B, Suzumura EA, Kimberlee R, Jones M, Pitkälä KH, Jansson AH, Litt JS, Siebert U, Rochau U.   +15 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Rare Pediatric Paratesticular Spindle Cell Rhabdomyosarcoma and Systematic Literature Review. [PDF]

J Investig Med High Impact Case Rep
Arja G, Salloum OH, Jaber J, Jubah T, Alrjoub S, Imran T, Alrjoub A, Hassouneh AWM, Natsheh M.   +8 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Pulmonary thromboembolism in Glanzmann Thrombasthenia: a case report and systematic literature review. [PDF]

Ann Hematol
Mohammad Alizade T, Karimi R, Kazemizadeh H, Khoshnam Rad N.   +3 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Treatment of Xanthoma disseminatum - a systematic literature review. [PDF]

J Dtsch Dermatol Ges
Hansen-Abeck I, Hillemans M, Abeck F, Schneider SW, Booken N.   +4 more
europepmc   +1 more source