Results 281 to 290 of about 2,543,955 (363)

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist.

Kátia Marie Senna (21807594), Ivan Ricardo Zimmermann (11146853), Márcia Gisele Santos da Costa (11307348), Bernardo Rangel Tura (7855931), José Ronyeryson dos Santos Evangelista (21807597), Marisa Santos (6072893)   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Image 6_A systematic review and meta-analysis of the effects of green tea extracts and polyphenols in female hormone-dependent cancers for benefit-risk evaluation.tif

Jin-jing He (22286767), Yan-fang Zhang (22286770), Ze-huang He (22286773), Lei Zheng (106363)   +3 more
openalex   +1 more source

Schinus molle L. Essential Oil: Chemotypes, Bioactive Compounds, and Pharmaceutical Insights: A Systematic Review [PDF]

Matteo Radice, Andrea Durofil, Sandra Ríos-Núñez, Miguel Angel Enríquez Estrella, Luis Humberto Vásquez Cortez, Mirtha Liliana Plaza Forenza, Reinier Abreu-Naranjo, Irene Gugel, Stefano Manfredini, Laura Scalvenzi   +9 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Greenspace exposure and associated health outcomes: a systematic review of reviews. [PDF]

F1000Res
Bryer B, Odebeatu CC, Lee WR, Vitangcol K, Gallegos-Rejas V, Osborne NJ, Williams G, Darssan D.   +7 more
europepmc   +1 more source

Image_2_The hidden crisis: double burden of malnutrition among refugee children in South Asia – a systematic review and meta-analysis from observational studies.JPEG

Pooja Panchal (20696588), Mohd Usman (12705540), Tajung Longkumer (20696591), Reshma Susan Babu (20696594), Mahalaqua Nazil Khatib (20696597), Shariza Abdul Razak (20696600), Kavitha Menon (20696603)   +6 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Effectiveness of Preventative Interventions to Reduce Mental Health Problems in at-risk Children and Young People: A Systematic Review of Reviews. [PDF]

J Prev (2022)
McGovern R, Balogun-Katung A, Artis B, Bareham B, Spencer L, Alderson H, Brown E, Brown J, Lingam R, McArdle P, Newham JJ, Wojciechowska A, Rankin J, Redgate S, Thomason P, Kaner E.   +15 more
europepmc   +1 more source

Table 1_Association of reallocating time between physical activity and sedentary behavior on the risk of depression: a systematic review and meta-analysis.docx

Yue Wang (65477), Jun Sun (48981), Yuheng Zhang (1543663), Jiali Wang (593779), Songtao Lu (1601377)   +4 more
openalex   +1 more source