Results 21 to 30 of about 552,583 (264)

Procalcitonin testing to guide antibiotic therapy for the treatment of sepsis in intensive care settings and for suspected bacterial infection in emergency department settings: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2015
Background: Determination of the presence or absence of bacterial infection is important to guide appropriate therapy and reduce antibiotic exposure.
Marie Westwood, Bram Ramaekers, Penny Whiting, Florian Tomini, Manuela Joore, Nigel Armstrong, Steve Ryder, Lisa Stirk, Johan Severens, Jos Kleijnen   +9 more
doaj   +1 more source

A Systematic Review and Mixed Treatment Comparison of Pharmaceutical Interventions for Multiple Sclerosis

Neurology and Therapy, 2020
Background Since 2010, 27 mixed-treatment comparisons (MTCs) of disease-modifying therapies (DMTs) for multiple sclerosis have been published. However, there has been continued evolution in the field of MTCs.
Gavin Giovannoni, Shona Lang, Robert Wolff, Steven Duffy, Robert Hyde, Elizabeth Kinter, Craig Wakeford, Maria Pia Sormani, Jos Kleijnen   +8 more
doaj   +1 more source

Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis

Health Technology Assessment, 2015
Background: Patients with substantive bleeding usually require transfusion and/or (re-)operation. Red blood cell (RBC) transfusion is independently associated with a greater risk of infection, morbidity, increased hospital stay and mortality.
Penny Whiting, Maiwenn Al, Marie Westwood, Isaac Corro Ramos, Steve Ryder, Nigel Armstrong, Kate Misso, Janine Ross, Johan Severens, Jos Kleijnen   +9 more
doaj   +1 more source

Rapid fetal fibronectin testing to predict preterm birth in women with symptoms of premature labour: a systematic review and cost analysis

Health Technology Assessment, 2013
Background: Premature birth is defined as birth of before 37 completed weeks' gestation. Not all pregnant women showing symptoms of preterm labour will go on to deliver before 37 weeks' gestation. Hence, addition of fetal fibronectin (fFN) testing to the
SN Deshpande, ADI van Asselt, F Tomini, N Armstrong, A Allen, C Noake, K Khan, JL Severens, J Kleijnen, ME Westwood   +9 more
doaj   +1 more source

Systematic literature reviews

Complementary Therapies in Medicine, 2005
Systematic reviews retrieve, appraise and summarise all the available evidence on a specific health question. They are designed to reduce the effect of the reviewers' own bias, and a full protocol should be written to define and guide the process. The appropriate resources should be in place before undertaking a review.
Adrian, White, Katja, Schmidt
openaire   +2 more sources

Mpox surveillance in endemic regions: a scoping review of trends, challenges, and recommendations

BMC Infectious Diseases
Background Mpox continues to pose a significant public health threat in endemic regions of Africa, particularly with the emergence of new viral clades and continuous human-to-human transmission.
Fortune Benjamin Effiong, Emmanuel Ebuka Elebesunu, Tolulope Joseph Ogunniyi, Dimeji Abdulsobur Olawuyi, Emmanuel Ekpor, Monica Ahiadorme, Archibong Edem Bassey, Ibrahim Adebayo Hassan, Emmanuella Benjamin Effiong, Oluwaseun Adeolu Ogundijo, Ayomide Timilehin Kayode, Leonard Ighodalo Uzairue   +11 more
doaj   +1 more source

Systematic Review and Network Meta‐Analysis on the Efficacy of Evolocumab and Other Therapies for the Management of Lipid Levels in Hyperlipidemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors evolocumab and alirocumab substantially reduce low‐density lipoprotein cholesterol (LDL‐C) when added to statin therapy in patients who need additional LDL‐C reduction ...
Peter P. Toth, Gillian Worthy, Shravanthi R. Gandra, Naveed Sattar, Sarah Bray, Lung‐I. Cheng, Ian Bridges, Gavin M. Worth, Ricardo Dent, Carol A. Forbes, Sohan Deshpande, Janine Ross, Jos Kleijnen, Erik S. G. Stroes   +13 more
doaj   +1 more source

Role of the faecal immunochemical test in patients with risk-stratified suspected colorectal cancer symptoms: A systematic review and meta-analysis to inform the ACPGBI/BSG guidelines

The Lancet Regional Health. Europe, 2022
Summary: Background: The UK National Institute for Health and Care Excellence (NICE), recommended in 2017 the use of the faecal immunochemical test (FIT) to guide investigations in patients presenting with NICE-defined low-risk symptoms suspicious for ...
Richard Booth, Rachel Carten, Nigel D'Souza, Marie Westwood, Jos Kleijnen, Muti Abulafi   +5 more
doaj   +1 more source

The problems with systematic reviews: a living systematic review

Journal of Clinical Epidemiology, 2023
Systematic reviews and meta-analyses are proliferating as they are an important building block to inform evidence-based guidelines and decision-making. Enforcement of best practice in clinical trials is firmly on the research agenda of good clinical practice, but there is less clarity as to how evidence syntheses that combine these studies can be ...
Uttley, L., Quintana, D.S., Montgomery, P., Carroll, C., Page, M.J., Falzon, L., Sutton, A., Moher, D.   +7 more
openaire   +3 more sources

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source