Results 231 to 240 of about 815,105 (301)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Binocular versus standard therapy for amblyopia - effect on visual acuity, adherence, and patient or caregiver reported outcomes: protocol for a systematic review. [PDF]

Syst Rev
Aleinati G, Alsamhan M, AlJassar R, Alhajeri S, AlAli A.   +4 more
europepmc   +1 more source

What are the experiences of women and girls in South Africa who access healthcare facilities as a result of sexual assault or sexual violence? [PDF]

, 2019
Hinsliff-Smith, K., McGarry, Julie, Randa, Moreoagae   +2 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The role of vasopressin in trauma resuscitation: a protocol of a systematic review and meta-analysis of randomized and observational studies. [PDF]

Scand J Trauma Resusc Emerg Med
Yousefi MR, Ghasemian M, Paydar S.
europepmc   +1 more source

i-HOP Guidebook: Using the Quality Assessment Tool for research concerning Children of Offenders [PDF]

, 2015
Christmann, Kris, Sharratt, Kathryn
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Developing a Best Practice Guideline for Clinical Practice in a Digital Health Environment: Systematic Reviews Based on the Grading of Recommendations, Assessment, Development, and Evaluation Approach. [PDF]

JMIR Nurs
Bailey L, Howitt L, Nizum N, Buchanan C, Charlebois M, Yoon J, RNAO Expert Panel.   +6 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Clinical application of dynamic visual acuity for detection of eye diseases: a scoping review protocol. [PDF]

BMJ Open
Tagoh S, Kwarteng MA, March De Ribot F.
europepmc   +1 more source