Results 151 to 160 of about 1,783,022 (384)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

PROTOCOL: Effects of social prescribing for older adults: An evidence and gap map

open access: yesCampbell Systematic Reviews
Objectives This is the protocol for an evidence and gap map. The objectives are as follows: The aim of this evidence and gap map is to map the available evidence on the effectiveness of social prescribing interventions addressing a non‐medical, health ...
Elizabeth Tanjong Ghogomu   +14 more
doaj   +1 more source

Systematic reviews and meta-analysis: Understanding the best evidence in primary healthcare

open access: yesJournal of Family Medicine and Primary Care, 2013
Healthcare decisions for individual patients and for public health policies should be informed by the best available research evidence. The practice of evidence-based medicine is the integration of individual clinical expertise with the best available ...
S Gopalakrishnan, P Ganeshkumar
doaj   +1 more source

How low can you go? Towards a hierarchy of grey literature. [PDF]

open access: yes, 2008
In recent times health sciences librarians have become increasingly involved in working closely with researchers who are undertaking literature reviews (often, but not always, systematic literature reviews).
Tyndall, Jessica
core  

Medical tourism research: A systematic review [PDF]

open access: yesInternational Journal of Infectious Diseases, 2010
Balaban, V., Marano, C.
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

MOESM2 of Crowdsourcing in health and medical research: a systematic review

open access: yes, 2020
Additional file 2: Table S8. Bias assessment of 17 studies examining a crowdsourcing approach to surgical technique evaluation.
Wang, Cheng   +14 more
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Systematic reviews: a cross-sectional study of location and citation counts

open access: yesBMC Medicine, 2003
Background Systematic reviews summarize all pertinent evidence on a defined health question. They help clinical scientists to direct their research and clinicians to keep updated.
Morgan Douglas   +3 more
doaj   +1 more source

National vs. international journals: views of medical professionals in Croatia [PDF]

open access: yes, 2008
Scholarly journals, especially in non-English-speaking countries, may perform very different functions depending on whether they are published for national or international audiences.
Hren, Darko   +5 more
core   +1 more source

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