Results 261 to 270 of about 1,783,022 (384)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Advancing equity and value in United States healthcare: an umbrella review. [PDF]

Int J Equity Health
Naghibi D, Bloschichak A, Qin Q, Fiscella K.   +3 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Building capacity for education research among clinical educators in the health professions: A BEME (Best Evidence Medical Education) Systematic Review of the outcomes of interventions: BEME Guide No. 34

, 2015
Rabia Ahmed, Ameer Farooq, Dale Storie, Lisa Hartling, Anna Oswald   +4 more
openalex   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Barriers and facilitators for implementing patient-reported outcome measures in oncology practices: an umbrella review. [PDF]

Qual Life Res
Rammant E, Ramsey I, M de Ligt K, Mazariego C, Pogoda K, Schmidt H, Beernaert K, Lidington E, Javan RC, Koczwara B, Sztankay M, van de Poll-Franse L, Van Hemelrijck M, EORTC quality of life group.   +13 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Nutrition Outcomes and Interventions in Older People in Africa: A Systematic Umbrella and Scoping Review. [PDF]

Nutr Rev
Manyara AM, Manyanga T, Naidoo S, Mattick K, Chingono R, Pearson GME, Babatunde O, Naidoo N, Ward KA, Gregson CL.   +9 more
europepmc   +1 more source

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease [PDF]

, 2017
Abas, Adinegara B.L., Ballas, Samir K., Dixit, Ruchita, Godinho, Myron A., Moe, Soe, Pal, Sudipta, Ram, Shanker, Yousuf, Uduman A.M.   +7 more
core   +2 more sources

Systematic Review of Research, Mentorship, and Career Resources for Medical Students Pursuing Neurosurgical Training

, 2023
Ashley Carter, Matthew C. Findlay, Emma R. Earl, Majid Khan, Sawyer Z. Bauer, Koorosh Farsi, Brandon Lucke‐Wold, Michael Karsy   +7 more
openalex   +1 more source