Results 91 to 100 of about 372,756 (303)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Scientific DataMegachile sculpturalis Smith, 1853 native to East Asia, is an important solitary bee species that has invaded both Europe and the United States. This study provides the first chromosome-level genome assembly of M.
Guang Yang +11 more
doaj +1 more source
Using CMB lensing to constrain the multiplicative bias of cosmic shear
, 2011 Weak gravitational lensing is one of the key probes of cosmology. Cosmic shear surveys aimed at measuring the distribution of matter in the universe are currently being carried out (Pan-STARRS) or planned for the coming decade (DES, LSST, EUCLID, WFIRST).
Alberto Vallinotto +7 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Projectile fragmentation of 129Xe at Elab=790 AMeV
, 1998 We have measured production yields and longitudinal momentum distributions of projectile-like fragments in the reaction 129Xe + 27Al at an energy of Elab=790 AMeV.
A. S. Goldhaber +28 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Complete chloroplast genome of Micractinium singularis MM0003 (Chlorellaceae, Trebouxiophyceae)
Mitochondrial DNA. Part B. Resources, 2020 The chloroplast genome of Micractinium singularis MM0003 was completely sequenced. This plastome has 139,597 bp in length and consists of 106 genes including 77 protein-coding, 3 rRNA, and 26 tRNA genes. The overall GC content of the genome is 34.0%.
Seung-Woo Jo +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Comparative analysis of stereotypical behavior with hunting in small mammals as an example
Экспериментальная психология, 2016 Comparative analysis of stereotypical behavioral patterns including elements of flexible behavior is presented, with hunting behavior of small mammals as an example.
Y.V. Levenets +2 more
doaj +1 more source